Simmondsin was modified with acarviosine-glucose using the transglycosylation activity of Thermus maltogenic amylase to synthesize a novel compound with both antiobesity and hypoglycemic activity. The LC/MS and 13C NMR analyses confirmed that the structure of the major transglycosylation product was acarviosine-simmondsin (Acv-simmondsin), in which acarviosine was attached to the glucose moiety...

PURPOSE To quantitatively assess and compare the anterior chamber volume (ACV) by different anterior segment imaging techniques. METHODS Forty healthy eyes of 40 patients were recruited and three consecutive measurements of ACV were determined prospectively utilizing SL-OCT and Pentacam. Statistical significance of interdevice differences between measurements was evaluated by unpaired t test ...

This study was performed to investigate the pharmacokinetics of valaciclovir (VACV), aciclovir (ACV) and 9-(carboxymethoxy)methylguanine (CMMG) in Japanese chronic hemodialysis patients following a single oral administration of 1000 mg VACV and the influence of genetic polymorphisms of aldehyde dehydrogenase-2 (ALDH2) on their pharmacokinetics. A total of eighteen individuals genotyped as ALDH2...

ACV is an effective agent for the treatment and prophylaxis of HSV infections in both IC and immunologically normal individuals. The drug is well tolerated in both populations and is not significantly associated with clinical or laboratory toxicities. Because of the great potential benefit and low risk, organ transplant recipients and patients with hematologic malignancies undergoing induction ...

バラシクロビル（valacyclovir: VACV）は，アシクロビル（acyclovir: ACV）のプロドラッグで，小児での腎障害の報告は稀である．症例は14歳女児，帯状疱疹の診断で前医にてVACV 3,000 mg/日を処方された．内服3日後から嘔吐し，頸部痛・頭痛・背部痛を訴え，内服7日目に全身浮腫が出現した．同日，前医血液検査で腎障害を認め入院となったが，乏尿が持続し翌日当院へ転院した．VACVによる薬剤性腎障害を疑い，血中ACV除去目的に入院5日目，7日目に血液透析を実施した．入院10日目の腎生検で，糸球体・間質に炎症細胞浸潤や結晶形成は認めず，広範囲に尿細管壊死を呈しており，VACVによる中毒性腎障害を考えた．後日，内服7日目の保存血清を用い血中ACV濃度を測定すると，10.69 µg/mL（至適治療濃度：0.8–1.6 µg/mL）と異常高値であった．VACVは正常腎...

    Acyclovir (9-[2-hydroxyethoxymethyl] guanine) is an acyclic nucleoside analogue of guanosine which is a potent and selective antiviral agent. Acycloviris converted to the monophosphate by thymidine kinase the virus-specific form of this enzyme and is subsequently converted to the triphosphate by the host cell kinase. Acyclovir triphosphate inhibits viral DNA-polymerase terminating the chain...

The majority of cases of acute encephalitis remain of unknown etiology despite extensive diagnostic evaluations [1, 2]. Herpes simplex virus (HSV) is the most common identified cause of acute sporadic encephalitis in the Western world, accounting for approximately 20% of total cases of identified cause [3]. Classic studies by the National Institute of Allergy and Infectious Diseases Collaborati...

Glycerol-stabilised cell extracts of Streptomyces clavuligerus contain an enzyme activity which synthesises ACV from the individual amino acids L-a-aminoadipic acid, t-cysteine and L-valine. Enzyme activity was optimum in reaction mixtures containing 1 mM ATP together with an ATP regenerating system. The ACV synthetase enzyme formed ACV analogs when provided with Lcarboxymethylcysteine in place...

Background: The oxidant-antioxidants balance in the living organism is constantly challenged by internal and external pressures. Maidenhair or Adiantum capillus-veneris (Acv) is rich in bioactive compounds with antioxidant effects.  Objectives: The present study aimed at investigating the effect of Acv hydroalcoholic extract on the oxidative stress rate of blood and brain of mice in the depres...

Recent epidemiological studies suggested that calcifications of the aorta and the coronary arteries are important predictors for cardiovascular morbidity and mortality. However, the relation between blood pressure components and the progression of vascular wall calcification has remained unclear. We quantified calcium deposits in the abdominal aorta as the percentage of aortic calcification vol...