Please cite this article in press as: Steensberg, A. Beyond biomarkers in drug discovery and d 1359-6446/ 2014 Elsevier Ltd. All rights reserved. http://dx.doi.org/10.1016/j.drudis.2014.12.009 market; this is no longer a certainty. Today, most new drugs compete against numerous therapies, including nonpharmaceutical options. To create new value these therapies need to provide benefits beyond ex...

During the past 25 years, a large amount of distributed virtual environment (DVE) systems has been proposed. Each was built to support a single scenario. This not only makes it impossible to rank these various DVEs, it also obscures the effect of each of the algorithms used in those systems. This makes it very hard to select the algorithms for a new scenario unless this scenario is a fairly exa...

From Marco Polo to Richard Nixon, narratives of the encounter between Chinese and Westerners have been defining texts of European cultures and their descendants. Successive but sporadic reports from travellers, missionaries, diplomats, traders and others have provided a model of an alternative way of arranging people, of organizing their lives, of thinking about the state of being human; one th...

............................................................................................................................. 1 Dedication .......................................................................................................................... i Table of

In 1984 Bannai and Ito conjectured that there are finitely many distance-regular graphs with fixed valencies greater than two. In a series of papers, they showed that this is the case for valency 3 and 4, and also for the class of bipartite distance-regular graphs. To prove their result, they used a theorem concerning the intersection array of a triangle-free distance-regular graph, a theorem t...