We show that relative mean survival parameters of a semiparametric log-linear model can be estimated using covariate data from an incident sample and a prevalent sample, even when there is no prospective follow-up to collect any survival data. Estimation is based on an induced semiparametric density ratio model for covariates from the two samples, and it shares the same structure as for a logis...

Summary Covariate-adaptive randomization schemes such as minimization and stratified permuted blocks are often applied in clinical trials to balance treatment assignments across prognostic factors. The existing theory for inference after covariate-adaptive is mostly limited situations where a correct model between the response covariates can be specified or method has well-understood properties...

We consider the problem of clustering grouped and functional data, which are indexed by a covariate, and assessing the dependency of the clustered groups on the covariate. We assume that each observation within a group is a draw from a mixture model. The mixture components and the number of such components can change with the covariate, and are assumed to be unknown a priori. In addition to lea...

In flood frequency analysis, expanding the additional information with hydrological reasoning beyond local at-site samples can be very useful for improving accuracy of distribution (FFD) estimation as well reflecting a better understanding characteristics. this study, river network-based hierarchical model is developed to estimate FFDs in Upper Yangtze basin by making full use both dependence w...

A general method for constructing low-rank tensor product smooths for use as components of generalized additive models or generalized additive mixed models is presented. A penalized regression approach is adopted in which tensor product smooths of several variables are constructed from smooths of each variable separately, these "marginal" smooths being represented using a low-rank basis with an...

Data on litter production traits of does, involving 1120 litters, was collected over a 10-year period (1984 to 1994) and analyzed to estimate heritability and repeatability. Locally adapted does and bucks of predominantly New Zealand White breeding were involved. Traits studied were total litter size born and born alive, and litter size and weight at 21 days, 28 days (weaning) and 84 days (mark...

PURPOSE To characterize the population pharmacokinetics of topotecan lactone in children with cancer and identify covariates related to topotecan disposition. PATIENTS AND METHODS The study population consisted of 162 children in seven clinical trials receiving single agent topotecan as a 30-min infusion. A population approach via nonlinear mixed effects modeling was used to conduct the analy...