Motivated by molecular data on female premutation carriers of the fragile X mental retardation 1 (FMR1) gene, we present a new method of covariate adjusted correlation analysis to examine the association of messenger RNA (mRNA) and number of CGG repeat expansion in the FMR1 gene. The association between the molecular variables in female carriers needs to adjust for activation ratio (ActRatio), ...

Classical quantitative genetics has applied linear modeling to the problem of mapping genotypic to phenotypic variation. Much of this theory was developed prior to the availability of molecular biology. The current understanding of the mechanisms of gene expression indicates the importance of nonlinear effects resulting from gene interactions. We provide a bridge between genetics and gene netwo...

Parental lines, namely: F1, F2, BC1, BC2, BC11, BC12, BC21, BC22, BC1 selfed, and BC2 selfed generations of three crosses involving six cultivars of durum wheat (Triticum durum Desf.) were studied for awn length under normaland late-sown environments to analyze the nature of gene effects and components of heterosis (over the better parent). A sixparameter model in the cross Cocorit 71 x A-9-30-...

Knowledge of the nature and magnitude of gene effects, as well as their contribution to the control of metric traits, is important in formulating efficient breeding programs for the improvement of plant genetics. Information concerning a genetic parameter such as the additive-by-additive epistatic effect can be useful in traditional breeding. This report describes the results obtained by applyi...

Unconditional quantile treatment effects are difficult to estimate in the presence of fixed effects. Panel data are frequently used because fixed effects or differences are necessary to identify the parameters of interest. The inclusion of fixed effects or differencing of data, however, changes the interpretation of the estimates. This paper introduces a quantile estimator for panel data which ...

The interrelationships among low density lipoprotein (LDL) particle size, plasma triglyceride (TG), and high density lipoprotein cholesterol (HDL-C) are well established and may involve underlying genetic influences. This study evaluated common genetic effects on LDL size, TG, and HDL-C by using data from 85 kindreds participating in the Genetic Epidemiology of Hypertriglyceridemia (GET) Study....

A simulation study was conducted to address the issue of how purely additive (simple) genetic architecture might impact on the efficacy of parametric and non-parametric genomic prediction methods. For this purpose, we simulated a trait with narrow sense heritability h2= 0.3, with only additive genetic effects for 300 loci in order to compare the predictive ability of 14 more practically used ge...

due to cereal are affected by drought stress in their lifetime. in order to study gene action of bread wheat under drought stress condition, a generation mean analysis was performed using f1, f2 and f3 generations derived from roushan and kavir. generation mean analysis was performed based on joint scaling test. genetic parameters including additive effect (d), dominance effect (h), additive×ad...