background: the purpose of this research was to determine the relation between negative or positive qualitative troponin i test and the short term prognosis of patients presenting to emergency department with chest pain or angina equivalent symptoms. methods: we assessed the qualitative rapid troponin i in patients with chest pain or angina equivalent symptoms after at least 4 hours and then we...

Adenine nucleotides represent crucial immunomodulators in the extracellular environment. The ectonucleotidases CD39 and CD73 are responsible for sequential catabolism of ATP to adenosine via AMP, thus promoting an anti-inflammatory milieu induced by “adenosine halo”. AMPD2 intracellularly mediates AMP deamination IMP, thereby both enhancing degradation inflammatory reducing formation adenosine....

Ludwig's angina was first detailed by the German surgeon Wilhelm Friedrich von Ludwig in 1836. We present a case which needed awake fibreoptic intubation due to severe trismus and a prolonged period intubated in the Intensive Care Unit after incision and drainage of neck spaces and removal of his lower wisdom teeth. He was finally discharged a week after admission and followed up in the outpati...

The classical model of coronary physiology implies the presence of maximal microcirculatory vasodilation during myocardial ischemia. However, Doppler monitoring of coronary blood flow (CBF) documented severe microcirculatory vasoconstriction during pacing-induced ischemia in patients with coronary artery disease. This study investigates the mechanisms that underlie this paradoxical behavior in ...

assessment of the efficacy of propranolol and diltiazem on the intensity, duration and periods of pain in the angina patients referred to the heart clinic of the shahrekored university of medical sciences khaledi a1, elahei n2,moradi m3, salehi sh4* received: 7 sep , 2013 accepted: 16 nov , 2013 abstract background & aims: ischemic heart disease is one of the most common, chronic and deadly dis...

BACKGROUND We tested the hypothesis that rest asynergy in collateral-dependent myocardium correlates with coronary steal. METHODS AND RESULTS PET with [13N]ammonia measured myocardial blood flow and flow reserve in 15 patients with symptomatic chronic ischemic heart disease. Coronary angiography assessed stenosis severity and collateral blood supply. Echocardiography or contrast ventriculogra...

Adenosine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Receptors [110]) are activated endogenous ligand adenosine (potentially inosine also at A3 receptors). Crystal structures for antagonist-bound [153, 313, 221, 61], agonist-bound [375, 203, 204] and G protein-bound A2A [49] have been described. The of an A1 receptor [128] adenosine-bound receptor-Gi complex [86] resolve...

Background and Aims: Percutaneous coronary interventions have been provided in various hospitals of Nepal for more than two decades. Hence, we aimed to study the percutaneous intervention revascularization status patients with artery disease at a tertiary center eastern Nepal.
 Methods: A cross sectional was conducted Birat Medical College Teaching Hospital from 1st Aug 30th Feb 2023. Nine...