BACKGROUND Therapeutic drug monitoring of adalimumab (ADM) has been introduced recently. When no detectable ADM serum concentrations can be found, the formation of antidrug antibodies (ADA) should be investigated. A variety of assays to measure the occurrence of ADA have been developed. Results are expressed as arbitrary units or as a titration value. The aim was to develop a monoclonal antibod...

OBJECTIVE To assess vitreous and plasma changes of vascular endothelial growth factor A (VEGF-A), adrenomedullin (ADM) and endothelin-1 (ET-1) in proliferative diabetic retinopathy (PDR). PATIENTS AND METHODS 9 patients with PDR in type 2 diabetes (T2DM) and 11 age-matched non-diabetic patients were enrolled. The levels of VEGF-A, ADM and ET-1 were measured using an enzyme (ELISA) and a radio...

Image inpainting in wavelet domains refers to the recovery of an image from incomplete and/or inaccurate wavelet coefficients. To reconstruct the image, total variation (TV) models have been widely used in the literature, and they produce high-quality reconstructed images. In this paper, we consider an unconstrained, TV-regularized, 2-data-fitting model to recover the image. The model is solved...

The metastatic behavior of a murine fibrosarcoma (UV-2237M-ADMR) resistant to Adriamycin (ADM) (doxorubicin) was investigated. Subclones isolated from the UV-2237M-ADMR line, which originated from a single colony, generally displayed a similar degree of resistance to ADM (eight out of nine clones did not differ from this UV-2237M-ADMR line). In contrast, they differed significantly in their cap...

The aim of the present study was to evaluate the association between DNA methylation and multidrug resistance (MDR) in glioma and identify novel effectors responsible for MDR in human gliomas. An MDR glioma cell line, SGH-44/ADM, was developed using adriamycin (ADM) impulse treatment. Cryopreservation, recovery and withdrawal were performed to evaluate the stability of SGH-44/ADM cells. The adh...

Ouabain (OUA) inhibited 86Rb uptake (50% inhibitory concentration = 0.8 X 10(-4) M) over concentration ranges close to those at which it caused a reversible cytotoxicity (50% lethal dose = 2.5 X 10(-4) M) in growing wild-type C3H/10T1/2 cells. On the other hand, Adriamycin (ADM) inhibited 86Rb uptake (50% inhibitory concentration = 2 X 10(-3) M) but at concentrations 10(4)-fold higher than thos...

In this article we review the Adomian decomposition method (ADM) and its modifications including different modified and parametrized recursion schemes, the multistage ADM for initial value problems as well as the multistage ADM for boundary value problems, new developments of the method and its applications to linear or nonlinear and ordinary or partial differential equations, including fractio...

In response to inflammation, pancreatic acinar cells can undergo acinar-to-ductal metaplasia (ADM), a reprogramming event that induces transdifferentiation to a ductlike phenotype and, in the context of additional oncogenic stimulation, contributes to development of pancreatic cancer. The signaling mechanisms underlying pancreatitis-inducing ADM are largely undefined. Our results provide eviden...

An interesting and real world problem is discussed in this paper in the kind of observer design of time-varying singular systems (Transistor Circuits). The results (approximate solutions) obtained using the Adomian Decomposition Method (ADM) and Singleterm Haar wavelet series (STHW) [12] methods are compared with the exact solutions of the time-varying singular systems. It is found that the sol...

The absorption of adriamycin (ADM) through the rat bladder epithelium was investigated histologically with a fluorescence microscope. ADM permeated through the epithelium into the lamina propria or the inner layer of the muscle within 15 min after instillation, but no further infiltration into the deeper part of the bladder wall was observed thereafter. In addition, fluorescence histological ev...