The aim of this study was to compare the growth response of 22 short pre-pubertal children without growth hormone deficiency, treated with a single daily growth hormone injection (group A), to the growth response of 27 similar children, treated with the same daily dose divided into 2 subcutaneous injections per day (group B), for 1 y, in a randomized study. GH treatment significantly promoted g...

In a previous study, F-actin appeared to play a key role in guiding microtubules during growth cone-target interactions. Here, F-actin flow patterns were assessed to investigate the relationship among F-actin flow, microtubule/organelle protrusion, and rates of outgrowth. We first demonstrated conditions in which surface markers (beads) moved at the same rate as underlying F-actin. These beads ...

Railways were integral to the development of the Indian economy before World War I. In this paper, we present new estimates of total factor productivity (TFP) for railways from 1874 to 1912, which highlight the strong performance of this key industrial sector. We find railway-industry TFP growth to be substantial, averaging 2.5 percent per year and generating a 3 percent social savings for the ...

Editorial The article in this issue of The Journal by Beck, Amento, and colleagues (1) is a landmark in its conceptual approach to the use of peptide growth factors for experimental wound healing and presages important clinical applications in the future. As background, it has been known for more than 10 years that direct application of peptide growth factors (cytokines) to an experimental woun...