Editorial Adverse drug reaction of the month-a new series This issue of the Postgraduate Medical Journal sees the launch of a new series of articles, Adverse drug reaction of the month. The series has two objectives. First, it is intended to inform practising clinicians about significant adverse reactions (ADRs), as well as their diagnosis, management and prevention. Second, we unashamedly wish...

In response to the challenges set forth by the 2 Social Media Mining for Health Applications Shared Task 2017, we describe a framework to automatically detect Twitter tweets with mentioned adverse drug reactions (ADRs). We used a dataset with 10822 annotated tweets provided by the event organizers to develop a framework comprised of a preprocessing module, 6 feature extraction modules, and one ...

The prevalence of social media has resulted in spikes of data on the Internet which can have potential use to assist in many aspects of human life. One prospective use of the data is in the development of an early warning system to monitor consumer Adverse Drug Reactions (ADRs). The direct reporting of ADRs by consumers is playing an increasingly important role in the world of pharmacovigilance...

BACKGROUND Pharmacovigilance is the "science and activities relating to the detection, assessment, understanding and prevention of adverse effects or any other drug related problems". Nepal joined the international pharmacovigilance programme as a full member in 2007. KIST Medical College, Lalitpur, Nepal joined the national programme as a regional centre from mid-July 2008. Currently, the patt...

Adverse drug reactions (ADRs) are a significant cause of morbidity and mortality and contribute to the incidence of adverse events, resulting in increased healthcare costs. Healthcare providers need to understand their role and responsibility in the detection, management, documentation, and reporting of ADRs, all essential activities for optimizing patient safety. The purpose of this article is...

On June 13, 2009, proposed regulations amending the Food and Drug Regulations1 with respect to adverse drug reaction reporting (“Proposed Regulations”) were published in the Canada Gazette. The Proposed Regulations permit more rigorous monitoring of drug safety by the Minister of Health and bolster the Minister’s ability to enforce Canada’s reporting requirements for adverse drug reactions.2 Un...

This paper describes our system used in the PSB 2016 Workshop on Social Mining Shared Task for adverse drug reaction (ADR) extraction in Twitter. Our system uses Conditional Random Fields to train a classifier for extracting ADR mentions. We leverage word representations from large amount of unlabeled tweets, both drug related and generic. Our experiment results show that cluster features deriv...

S : scientific #bd14 | big data conference 44 Dr Chen Wang Senior Research Scientist CSIRO Computational Informatics Dr Chen Wang is a Senior Research Scientist at CSIRO Computational Informatics. He received his PhD from Nanjing University. His research interests are primarily in distributed, parallel and trustworthy systems. His current work focus on data analytics systems for drug adverse re...

Globally, adverse drug reactions (ADRs), one of the leading causes of morbidity and mortality, will continue to pose a threat to public health as long as drugs are being used to treat various ailments. Prompt ADR reporting is crucial in ensuring drug safety. The aim of this narrative review was to highlight the role of pharmacists in pharmacovigilance and to identify barriers and facilitators t...

In this report we describe a 53-year-old woman with advanced non-small cell lung cancer, treated with pemetrexed and cisplatin combination therapy, followed by pemetrexed monotherapy. The patient developed severe muscle spasms at least twice, shortly after administration of pemetrexed monotherapy. A possible explanation for this observation is that in combination with cisplatin therapy, the pat...