objective: diabetes is one of the most common metabolic diseases. earlier diagnosis of diabetes and treatment of hyperglycemia and related metabolic abnormalities is of vital importance. diagnosis of diabetes via proper interpretation of the diabetes data is an important classification problem. classification systems help the clinicians to predict the risk factors that cause the diabetes or pre...

An increasing proportion of men are undergoing radical prostatectomy for locally advanced prostate cancer. More than half of men with adverse pathologic features are expected to experience disease recurrence within 10 years. This article discusses the use of postoperative radiation therapy to decrease this risk. Evidence from 3 randomized trials and multiple retrospective studies indicates that...

Intrathecal and systemic methotrexate (MTX), as well as cranial radiation, are effective modalities to prevent central nervous system relapse in childhood acute lymphoblastic leukemia. Leukoencephalopathy is a well-described adverse effect of MTX therapy and is associated with a wide range of neurological sequelae. Most recent studies of MTX-induced leukoencephalopathy have focused exclusively ...

While endolymphatic hydrops is a characteristic pathologic feature of Menière's disease, there are exceptions to this rule. There is evidence that hydrops develops as a result of malabsorption of endolymph. This implies dysfunction of the endolymphatic sac and duct, which normally absorb endolymph. In approximately 20% of cases of Menière's disease, a specific pathologic condition in the tempor...

Nuclear morphometry is a method for quantitative measurement of histopathologic changes in the appearance of stained cell nuclei. Numerous studies have indicated that these assessments may provide clinically relevant information related to the degree of progression and malignant potential of breast neoplasia. Nuclear features are derived from computerized analysis of digitized microscope images...

Although fever magnitude and etiology have been associated with outcomes of critically ill patients, possible associations between fever duration and mortality remain inconclusive. Since long-lasting fever is generally attributed to severe pathologic conditions, it is expected to be an indicator of adverse outcome. It also seems plausible that persistent fever in specific patient groups, mainly...

Although chronic granulomatous inflammation (CGI) with concomitant caseous necrosis (CN) is a characteristic histological feature of tuberculosis (TB), few studies have investigated its frequency or various pathologic findings. The medical records of 227 human immunodeficiency virus (HIV) -negative, culture-positive TB patients who underwent biopsy were studied. After the frequency of character...

male guinea pigs show high susceptibility to burkholderia mallei and have been used as animal models in glanders studies. the purpose of our study was to elucidate glanders comparative pathogenesis in guinea pigs. we present here the histological changes and bacterial isolation that develop over time in guinea pigs inoculated intraperitoneally (ip) with two strain of b. mallei. ten male guinea ...

the aim of this study was to assess the value of 99mtc-hexakis-2-methoxyisobutylisonitrile (mibi) scintigraphy in patients with clinical and radiologic features of primary or metastatic musculoskeletal tumors. methods: the scintigraphic findings for 84 patients were compared with the surgical and histologic findings. each patient underwent three-phase bone scan with 99mtc-methylene diphosphonat...

Activation-induced Fas ligand (FasL) mRNA expression in CD4+ T cells is mainly controlled at transcriptional initiation. To elucidate the epigenetic mechanisms regulating physiologic and pathologic FasL transcription, TCR stimulation-responsive promoter histone modifications in normal and alcohol-exposed primary human CD4+ T cells were examined. TCR stimulation of normal and alcohol-exposed cel...