نتایج جستجو برای: ag and gg genotypes were 005
تعداد نتایج: 16860919 فیلتر نتایج به سال:
This study was aimed to evaluate the influence of Human Leukocyte Antigens- G (HLA-G) gene polymorphisms on risk rheumatoid arthritis (RA). In present study, blood samples were collected from 100 patients and healthy controls. Serum levels HLA-G in both controls measured using ELISA kit which shown a higher significant differences (p< 0.05) comparison between them (539.3 ng/ml 139.3ng/ml) re...
Tumor necrosis factor-alpha (TNF-α) could be considered as potential biomarkers in atopic dermatitis (AD), while its level could be influenced by cytokine single gene polymorphisms (SNP). This study was performed in 89 pediatric patients with AD and 137 controls to assess polymorphisms of the TNF-α gene at positions -308 and -238, using the polymerase chain reaction and the sequence-specific pr...
oxidative stress is known to be one of the major factors involved in the development and progression of cancer. oxidative stress can occur due to an imbalance between concentrations of reactive oxygen species and antioxidant capacities. catalase (cat; omim 115500) and superoxide dismutase 1 (sod1; omim 147450) play important roles in the primary defense against oxidative stress. in the present ...
BACKGROUND C-fibers express transient receptor potential (TRP) channels. These high-voltage gated channels function as integrators of different physical stresses (e.g. heat, protons, ATP). Additionally channel activation can be induced by capsaicin. Topically applied, capsaicin elicits burning pain, heat and mechanical hyperalgesia and serves as a human surrogate model for pain. It was suggeste...
Pancreatic disorders have a high prevalence worldwide. Despite the fact that screening methods became more effective and the knowledge we have nowadays about pancreatic diseases has enhanced, their incidence remains high. Our purpose was to determine whether single nucleotide polymorphism (SNP) of VEGFR-2/KDR (vascular endothelial growth factor receptor 2/kinase insert domain receptor) influenc...
BACKGROUND Tumor necrosis factor (TNF) and TNF receptor superfamily (TNFR)-mediated immune response play an essential role in the pathogenesis of severe sepsis. Studies examining associations of TNF and lymphotoxin-α (LTA) single nucleotide polymorphisms (SNPs) with severe sepsis have produced conflicting results. The objective of this study was to investigate whether genetic variation in TNF, ...
Type 2 diabetes mellitus is a worldwide epidemic disorder with considerable health and economic consequences. Metformin is one of the most commonly prescribed oral antidiabetic drugs. Pharmacogenetic studies showed that variants in genes related to the pharmacokinetics of metformin were associated with glucose-lowering effect of metformin. The aim of this study was to evaluate pharmacogenetic v...
conclusions the results revealed a significant relationship between the gg genotype of ctla-4 and the increased risk of tb. results data analysis indicated that the frequencies of aa, ag and gg genotypes were 42%, 38%, and 20% in patients with tb and 43%, 47%, 1% in the control subjects, respectively. the gg genotype of ctla-4 (+49a/g) showed a significantly increased risk of disease (or = 20.4...
It has been reported that interleukin-10 (IL-10) promoter genes (1082 A/G, 819 T/C, 592 A/C) are associated with nasopharyngeal carcinoma (NPC). However, the results remain controversial and ambiguous. To resolve inconsistencies in published data, we performed a meta-analysis to ascertain the association between IL-10 polymorphisms and NPC risk. Two case-control studies and two cohort studies w...
PURPOSE To determine whether genetic factors that influence age-related macular degeneration (AMD) have an early pharmacogenetic effect on treating exudative AMD with ranibizumab in a Korean population. METHODS A retrospective study of 102 patients (70 with typical neovascular AMD and 32 with polypoidal choroidal vasculopathy) with exudative AMD treated with intravitreal ranibizumab monothera...
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