338 DR. BARNETT: I think few of us would consider that we know enough new about pyloric stenosis to justify presenting an infant with it to a group of this type. However, the patient to be presented had what appears to be a cornplication of p loric stenosis, which we had not encountered previously and one which is of both practical and theoretic interest. The patient will be described and the d...

338 DR. BARNETT: I think few of us would consider that we know enough new about pyloric stenosis to justify presenting an infant with it to a group of this type. However, the patient to be presented had what appears to be a cornplication of p loric stenosis, which we had not encountered previously and one which is of both practical and theoretic interest. The patient will be described and the d...

583 syndrome: behavioural changes, decreased muscle strength, heart defects, annular pancreas, aganglionic megacolon, immune defects and placental vascular abnormalities. So Arron et al. looked for genes in the DSCR that could regulate NFATc. They identified DYRK1A, which encodes a kinase, and DSCR1, which encodes a known inhibitor of calcineurin. The DYRK1A and DSCR1 proteins acted synergistic...

D evelopment of the nervous system depends on patterned neuronal migration and axonal growth, which are regulated by cell–cell and cell–substrate interactions (1). These interactions are mediated through cell adhesion molecules (CAMs), which include cadherins, selectins, integrins, mucins, and members of the IgG superfamily. Within the latter group are proteins, such as neural cell adhesion mol...

Total colonic aganglionosis (TCA) is a rare form of Hirschsprung disease (HD). It is difficult to be diagnosed on contrast enema because the radiographic findings are variable. The study aims to re-evaluate the contrast enema findings of TCA. From 2001 to 2009, 14 patients (11 males, 3 females; ages from 1 day to 6 months) with pathologically proven TCA were reviewed for demographic features, c...

The aim of this study was to examine MAP kinase (ERK1/2) activation in the human neonatal colonic enteric nervous system. For this, we investigated by immunocytochemistry the cellular localization of phosphorylated ERK1/2 (P-ERK) in a series of normal human colon samples removed from newborns and in patients with intestinal obstruction such as Hirschsprung’s disease (HSCR), stenosis and atresia...