In offshore structures, most of failures are caused by the lack of sufficient piles strength. Scour phenomena affects the load transition and the pile strength. The necessity of the consideration of scouring phenomena amplifies when the scour depth becomes remarkable, which can endanger the jacket stability. In this paper, a new method is used to consider the pile scouring using nonlinear pusho...

Collagen fibrils become resistant to cleavage over time. We hypothesized that resistance to type I collagen proteolysis not only marks biological aging but also drives it. To test this, we followed mice with a targeted mutation (Col1a1(r/r) ) that yields collagenase-resistant type I collagen. Compared with wild-type littermates, Col1a1(r/r) mice had a shortened lifespan and developed features o...

The condition of oil-paper insulation is closely related to the life expectancy of a transformer. The accurate results of oil-paper have not been obtained due to the impact of influencing factors. Therefore, in order to improve the evaluation accuracy of oil-paper insulation, in this paper, oil-paper samples which were prepared with different aging and moisture content were analyzed by frequenc...

Kinetin (Kn) is a cytokinin growth factor that exerts several anti-aging and antioxidant effects on cells and organs. To investigate the mechanism underlying apoptotic events in aging cells induced by D-galactose (D-gal), we examined the effect of Kn delivered via nuchal subcutaneous injection on D-gal-induced aging and apoptosis in rats. Our results showed that interleukin (IL)-2 levels and mi...

Reactive oxygen species (ROS) are closely related to the aging process. In our previous studies, we found that the saponins from Aralia taibaiensis have potent antioxidant activity, suggesting the potential protective activity on the aging. However, the protective effect of the saponins and the possible underlying molecular mechanism remain unknown. In the present study, we employed a D-galacto...

The HERA-B Outer Tracker consists of drift tubes folded from polycarbonate foil and is operated with Ar/CF4/CO2 as drift gas. The detector has to stand radiation levels which are similar to LHC conditions. The first prototypes exposed to radiation in HERA-B suffered severe radiation damage due to the development of self-sustaining currents (Malter effect). In a subsequent extended R&D program m...

Stem cells maintain tissues and organs over the lifespan of individuals. How aging influences this process is unclear. Here we investigate the effects of aging on C. elegans germline stem/progenitor cells and show that the progenitor pool is depleted over time in a manner dependent on inhibition of DAF-16/FOXO by insulin/IGF-1 signalling (IIS). Our data indicate that DAF-16/FOXO activity in cer...

The purpose of this study is to evaluate the effect of aging in either air or nitrogen on the residual interlaminar strains and stresses in unidirectional and woven graphite/polyimide composites. In order to accomplish this goal, XRD measurements have been made on embedded aluminum inclusions placed between the first and second plies of both unidirectional and fabric graphite /PMR-15 composite ...

the static strain aging is a phenomenon that can change the mechanical properties of low carbon steels. thus, the static strain aging behavior of low carbon steel wires after drawing process is studied. to do so, the wires are austenitized at different temperatures and cooled in different rates. then the wires are drawn and aged at a specific temperature and time. before and after aging of each...

The increase in oxidative stress that accompanies aging has been implicated in the abnormal advance of aging and in the onset of various systemic diseases. However, the details of what effects the increase in oxidative stress that accompanies aging has on saliva secretion are not known. In this study, naturally aging mice were used to examine the stimulated whole saliva flow rate, saliva and se...