Aicardi-Goutières syndrome (AGS) is a rare, autosomal recessively inherited, immune-mediated neurodevelopmental disorder. The syndrome causes infantile-onset progressive encephalopathy characterized by the neuroradiologic features of basal ganglia and periventricular white matter calcification, leucodystrophy and cerebral atrophy. Lymphocytosis and elevated levels of interferon alpha (IFN-alpha...

To evaluate and develop methodologies for the extraction of gel-forming extracellular polymeric substances (EPS), EPS from aerobic granular sludge (AGS) was extracted using six different methods (centrifugation, sonication, ethylenediaminetetraacetic acid (EDTA), formamide with sodium hydroxide (NaOH), formaldehyde with NaOH and sodium carbonate (Na2CO3) with heat and constant mixing). AGS was ...

Function-Described Graphs (FDGs) have been introduced by the authors as a representation of an ensemble of Attributed Graphs (AGs) for structural pattern recognition alternative to first-order random graphs. Both optimal and approximate algorithms for error-tolerant graph matching, which use a distance measure between AGs and FDGs, have been reported elsewhere. Also, the supervised synthesis of...

AIMS AND BACKGROUND Paxillin is a central protein within the focal adhesion and serves as a critical transducer of signals from fibronectin. Although abnormal expression of fibronectin and paxillin is often observed during the development of human malignancies, the relationship between paxillin and cell invasion in gastric cancer is still unclear. The current study was designed to investigate t...

The evaluation strategy (abbr. the E-strategy) initiated by OBJ2 is one of compromises between outermost and innermost reduction strategies. Although rewriting with the E-strategy is intuitively easy-to-understand, the straightforward implementation cannot lead to e cient rewriting. Then, the implementations of OBJ3 and CafeOBJ use evaluated ags to implement reasonably rewriting with the E-stra...

2 Abdulghani Sankari, MD, PhD* 3 Amy Bascom, RRT, MS 4 Susmita Chowdhuri, MD, MS 5 M. Safwan Badr, MD, MBA 6 7 Sleep Research Laboratory 8 John D. Dingell Veterans Affairs Medical Center 9 Wayne State University 10 4646 John R 11 Detroit, MI 48201 USA 12 *Corresponding Author: Division of Pulmonary, Critical Care and Sleep Medicine 13 3990 John R, 3-Hudson 14 Detroit, MI 48201 USA 15 Tel: (313)...

Mycobacterium tuberculosis is responsible for almost 2 million deaths annually. Mycobacterium bovis bacillus Calmette-Guérin, the only vaccine available against tuberculosis (TB), induces highly variable protection against TB, and better TB vaccines are urgently needed. A prerequisite for candidate vaccine Ags is that they are immunogenic and expressed by M. tuberculosis during infection of the...

Enhanced disease is the term used to describe the aberrant Th2-skewed responses to naturally acquired human respiratory syncytial virus (hRSV) infection observed in individuals vaccinated with formalin-inactivated viral Ags. Here we explore this paradigm with pneumonia virus of mice (PVM), a pathogen that faithfully reproduces features of severe hRSV infection in a rodent host. We demonstrate t...

We previously identified a distinct mutation pattern in the antibody genes of B cells isolated from cerebrospinal fluid (CSF) that can identify patients who have relapsing-remitting multiple sclerosis (RRMS) and patients with clinically isolated syndromes who will convert to RRMS. This antibody gene signature (AGS) was developed using Sanger sequencing of single B cells. While potentially helpf...

Hibernation is a unique physiological adaptation characterized by periods of torpor that consist of repeated, reversible, and dramatic reductions of body temperature, metabolism, and blood flow. External and internal triggers can induce arousal from torpor in the hibernator. Studies of hibernating animals often require that animals be handled or moved prior to sampling or euthanasia but this mo...