Abstract Exposure to social adversity can influence the onset and progression of disease. One possible mechanism through which may impact health outcomes is by altering immune homeostasis. Recently, evidence has connected changes in gene regulation response both humans nonhuman primates. We investigated how (quantified as low status) affected Th2 free-ranging male rhesus macaques (n=128). stimu...

The AKT kinase family is a high-profile target for cancer therapy. Despite their high degree of homology the three isoforms (AKT1, AKT2 and AKT3) are non-redundant can even have opposing functions. Small-molecule inhibitors affect all which severely limits usefulness as research tool or therapeutic. Using AKT2-specific nanobodies we examined function endogenous in breast cells. Two (Nb8 Nb9) mo...