See related article, pages 2457-2462. The signs and symptoms of acute intracranial hemorrhage are those of a rapidly developing mass lesion, compounded over time by surrounding edema, and sometimes by brain herniation. These are dramatic, debilitating, and often fatal events, but does the pathophysiology of intracranial hemorrhage extend beyond that of mass effect? Blood contains several factor...

Lupus erythematosus and vitiligo are diseases of autoimmune origin. Reports in the literature suggest patients are more likely to suffer more than 1 autoimmune disease (30% of patients with generalized vitiligo have another autoimmune disease).1 However, there are few reports of cutaneous lupus erythematosus in association with vitiligo. We describe a 42-year-old woman with no family history of...

The legalization of cannabis (marijuana) for medical and recreational purposes in states throughout the United States has greatly increased its availability and use by adults and teens. Much of the earlier research on cannabis focused on its administration by smoking. Very little recent research has been conducted on the administration of cannabis by the oral route, the presumption apparently b...

THE IMPORTANCE OF SLOW-WAVE SLEEP (SWS) DURING NOCTURNAL SLEEP IS WIDELY CONFIRMED. THE FACT THAT THE RATES OF CEREBRAL NEURAL FIRING are lowest during SWS, the length of SWS is correlated with the length of prior wakefulness, and the cerebrum is isolated from sensory input and from subcortical structures suggests that SWS is associated with tissue restitution.1 Recently, the recuperative effec...

In the United States, aortic aneurysms are the 13th leading cause of death.1,2 Approximately 15 000 individuals die every year because of the rupture of aortic aneurysms. On the basis of autopsy studies, it has been estimated that 1% to 2% of the population harbor aneurysms in their aorta, with up to 10% prevalence in older age groups.1,2 Most aortic aneurysms go undetected until rupture, and t...

Exercise and cardiorespiratory fitness have long been associated with reduced cardiovascular mortality and overall longevity in apparently healthy individuals and also in patients with pre-existing cardiovascular diseases.1,2 It is part of the general recommendations for lifestyle modifications in patients with early forms of cardiovascular disease and has been associated with changes in multip...

In this issue of the Journal, de Cremoux et al1 report a study examining the efficiency of human papillomavirus (HPV) testing using the Hybrid Capture 2 (HC2) in cervical cancer screening. In conducting this study, they focused on several factors that are emerging as important determinants of accuracy in the use of HC2 in any setting, including the following: (1) sensitivity, (2) positive predi...

Exercise and cardiorespiratory fitness have long been associated with reduced cardiovascular mortality and overall longevity in apparently healthy individuals and also in patients with pre-existing cardiovascular diseases.1,2 It is part of the general recommendations for lifestyle modifications in patients with early forms of cardiovascular disease and has been associated with changes in multip...

B oth observational and epidemiologic studies have identified clinical variables associated with a higher risk of mortality in patients with acute lung injury. The most consistent clinical risk factors for higher mortality have been sepsis as the cause of lung injury, chronic liver disease, underlying malignancy, older age, and higher severity of illness assessed by elevated acute physiology an...

Nitric Oxide and the Ryanodine Receptor Ca-Release Channel To the Editor: I have read with interest the recent review on the role of S-nitrosylation in cardiovascular signaling, in which Lima et al1 provide a very useful digest on the current status of research in this important but burgeoning field of cardiovascular physiology. On the other hand, I believe that one of the many functions of a s...