A previously published working model for the regulation of chlorophyll formation has been tested studying early steps of chlorophyll and porphyrin biosynthesis in developing cotyledons of Helianthus annuus. The activities of delta-aminolevulinate synthetase (ALAS), delta-aminolevulinate dehydratase (ALAD), and the porphobilinogenase complex (PBGase) at any given time have been found to be stron...

The presence of SF3B1 gene mutations is a hallmark of refractory anemia with ring sideroblasts (RARS). However, the mechanisms responsible for iron accumulation that characterize the Myelodysplastic Syndrome with ring sideroblasts (MDS-RS) are not completely understood. In order to gain insight in the molecular basis of MDS-RS, an integrative study of the expression and mutational status of gen...

BACKGROUND Human anxiety disorders are complex diseases with largely unknown etiology. We have taken a cross-species approach to identify genes that regulate anxiety-like behavior with inbred mouse strains that differ in their innate anxiety levels as a model. We previously identified 17 genes with expression levels that correlate with anxiety behavior across the studied strains. In the present...

Krüppel-like factor 1(KLF1) is a hematopoietic-specific zinc finger transcription factor essential for erythroid gene expression. In concert with the transacting factor GATA1, KLF1 modulates the coordinate expression of the genes encoding the multi-enzyme heme biosynthetic pathway during erythroid differentiation. To explore the mechanisms underpinning KLF1 action at the gene loci regulating th...

0957-4174/$ see front matter 2012 Elsevier Ltd. A http://dx.doi.org/10.1016/j.eswa.2012.05.040 ⇑ Corresponding author. Tel.: +90 312 2977900. E-mail address: [email protected] (C.H. Alad In recent years, time series forecasting studies in which fuzzy time series approach is utilized have got more attentions. Various soft computing techniques such as fuzzy clustering, artificial neural net...

PARK initially reported z the accumulation of amino acid containing nucleotides in penicillin-treated Staphylococcus aureus. Subsequent work% s has shown that the structure of one of these nucleotides is UDP-GNAc-lactyl-L-Ala-D-Glu-L-Lys-D-Ala-D-Ala. Nucleotides lacking one or more of these amino acids ("incomplete peptides") have also been isolated from this organism. A similar nucleotide cont...

The Tri-State Mining District (Oklahoma, Kansas, and Missouri) is contaminated with Pb, Cd, and Zn from mining, milling and smelting. Metals have been dispersed heterogeneously throughout the District in the form of milled mine waste ("chat"), as flotation tailings and from smelters as aerial deposition or slag. This study was conducted to determine if the habitat has been contaminated to the e...

Supply of cadmium chloride (0.5 mM) inhibited chlorophyll formation in greening maize leaf segments, while lower concentration of Cd (0.01 mM) slightly enhanced it. Inclusion of 2-oxoglutarate (2-OG, 0.1-10 mM) in the incubation mixture increased chlorophyll content in the absence as well as presence of Cd. Substantial inhibition of chlorophyll formation by Cd was observed at longer treatment b...

Glutathione transferase zeta (GSTZ1-1) catalyzes the isomerization of maleylacetoacetate (MAA) to fumarylacetoacetate, the penultimate step in the tyrosine degradation pathway. GSTZ1-1 is inactivated by dichloroacetic acid (DCA), which is used for the clinical management of congenital lactic acidosis and is a drinking-water contaminant. Metabolic changes associated with chemically induced GSTZ1...

The objective of the present study was to evaluate the protective efficacy of gossypin coadministration during lead-ethanol co-exposure. In one of our earlier study we reported the protective efficacy of gossypin against lead induced oxidative stress and it was of interest to observe the efficacy in the situation of combined lead-ethanol exposure. Animals were exposed to lead as lead nitrate (2...