The chemoprotective effects of combined ebselen and allopurinol in breast (MTLn3) and ovarian (NuTu-19) cancer models using a repeated cisplatin dosing schedule (6 mg/kg i.p.x3 weeks) were studied. Otoprotection was evaluated using auditory evoked brainstem response (ABR) to determine threshold and latency shifts, and outer hair cell counts. Nephroprotection was analyzed by serological markers ...

Serum haematology and biochemical profile of weaner rabbits fed graded levels of yam peels replacing maize were evaluated. The experiment which lasted fifty-six days using 15 weaner rabbits was laid in a randomized complete block design using five dietary treatments with three replications each. The dietary treatments evaluated were 5%, 10%, 15%, 20% and 0% inclusion level of yam peels replacin...

BACKGROUND The present study was carried out to investigate the possible protective effects of royal jelly (RJ) on oxymetholone (OXM)-induced oxidative liver injuries in mice. METHODS In total, 32 adult male NMRI mice were divided into four groups of eight mice each. Mice in groups 1 and 2 were orally administered 5 mg/kg/day OXM for 30 days. At the same time, mice in group 3 received RJ at a...

Effect of polyherbal formulation Ambrex was evaluated in butylated hydroxytoluene (BHT) induced toxicity of lungs and liver in rats. Toxicity was produced by administering BHT (500 mg/kg/day) for 3 days. Lung damage was evidenced by elevated levels of broncho alveolar lavage fluid (BAL) parameters such as protein, lactate, lactate dehydrogenase (LDH), alkaline phosphatase (ALP), acid phosphatas...

OBJECTIVE This study examined the effects of thiamine and thiamine pyrophosphate on oxidative damage developing in association with hepatic injury caused by alcohol toxicity in rats and on hepatic injury markers. MATERIALS AND METHODS Four groups of rats were used; control, a group receiving thiamine+ethanol, a group receiving thiamine pyrophosphate+ethanol and a healthy group. The experiment...

BACKGROUND This study investigated the hepatoprotective effect and antioxidant properties of phloroacetophenone (2',4',6'-trihydroxyacetophenone - THA), an acetophenone derived from the plant Myrcia multiflora. MATERIAL #ENTITYSTARTX00026; METHOD The free radical scavenging activity in vitro and induction of oxidative hepatic damage by carbon tetrachloride (CCl(4)) (0.5 ml/kg, i.p.) were test...

Soybean and its isoflavones have been shown to have beneficial effects on carbohydrate and lipid metabolism and on renal function. Probiotics may potentiate the beneficial effects of isoflavones by converting the inactive isoflavone glycoside to aglycones, which are biologically active, thereby producing a synergistic effect. We therefore studied the effects of soybean isoflavones in the presen...

OBJECTIVE To determine the nature and outcome of obstetric cholestasis in a United Kingdom population. DESIGN Prospective analysis of clinical outcome in women diagnosed with obstetric cholestasis that is actively managed. SETTING Antenatal population of three London hospitals between August 1999 and April 2001. POPULATION Seventy women with obstetric cholestasis defined as abnormal liver...

The study is to evaluate the effect of age and sex on serological indices of Japanese quail (Coturnix coturnix japonica) reared in derived savanna area of Nigeria. A total of 200 quails comprising 100 each of male and female were selected for this study. Fifteen each of the males and females quails were randomly selected at each week of 6, 7, 8, 9, 10 and 11 respectively. Data were obtained on ...

BACKGROUND Cabergoline is a long-acting agonist of dopamine, which has a high affinity to dopamine receptors (type 2). Treatment using a dopaminergic agonist reduces hypothalamic stimulation that increases during liver gluconeogenesis, lipids synthesis, and insulin resistance. Our aim was to evaluate the effects of cabergoline on blood glucose levels in patients with type 2 diabetes mellitus (D...