BACKGROUND Patients undergoing liver resection are at risk for intraoperative hyperglycemia and acute hyperglycemia is known to induce hepatocytes injury. Thus, we aimed to evaluate whether intraoperative hyperglycemia during liver resection is associated with the extent of hepatic injury. METHODS This 1 year retrospective observation consecutively enrolled 85 patients undergoing liver resect...

Large numbers of antibiotics have been discovered in the past 40 years and manymethods have been employed for discovery of novel antibiotics. Oneof them is the use of mutants that are highly sensitive to antibiotics. Recently /2-lactam antibiotic-hypersensitive mutants of Escherichia colil) and Pseudomonas aemginosa2) and an aminoglycoside-hypersensitive mutant of Klebsiella pneumoniaez) have b...

ABSTRACT A 13-year-old boy known for steroid-resistant nephrotic syndrome taking cyclosporine the last four years was referred from one private hospital non-response to treatment and decreased hearing. On detailed history, it revealed that hearing loss started after initiation of with during first year, patient not properly followed issues. Rather continued despite no response treatment. The ra...

Using a chemically defined medium without L-alanine, Lactobacillus johnsonii was demonstrated to be strictly auxotrophic for that amino acid. A comparative genetic analysis showed that all known genes involved in L-alanine biosynthesis are absent from the genome of L. johnsonii. This auxotrophy was complemented by heterologous expression of the Bacillus subtilis L-alanine dehydrogenase.

Background: The reported statistics suggest that alcoholic liver disease is on the rise. Furthermore, medications used to treat have unpleasant effects, and this necessitates need continuously investigate hepatoprotective agents. This study investigates animal models of evaluate activity. Content: A good number published articles evaluating activity were summarized. studies three ethanol-induce...

The simultaneous application of chemical modification of primary amines and the insertion of a lgF probe have been used to detect the nature and physical properties of the amino group influencing a selected region of the active center of the enzyme aspartate aminotransferase. The enzyme, carbamylated at the NH,-terminal alanine (transaminase’, produced from cyanate-treated holoenzyme) or at the...