We have developed TM-align, a new algorithm to identify the best structural alignment between protein pairs that combines the TM-score rotation matrix and Dynamic Programming (DP). The algorithm is approximately 4 times faster than CE and 20 times faster than DALI and SAL. On average, the resulting structure alignments have higher accuracy and coverage than those provided by these most often-us...

Enterprise CIOs focus to deliver return on investment and/or provide strategic advantage with applications and services that align to the business (and difficult for competitors to copy). Most CIOs have excess capacity and a huge investment in equipment. With an oversupply of servers and constant requests for more, they are looking to use their internal infrastructure more effectively. The rece...

We study the problem of a two-firm supply chain in which firms simultaneously choose a capacity before demand is realized. We focus on the role that private information about demand has on firms’ ability to align their capacity decisions. When forecasts are private information, there are at most two equilibria: a complete coordination failure or a monotone equilibrium in which firms earn positi...

To the extent that the sexes typically occupy different social roles, these roles frame individual opportunities in ways that foster differences in motivations and different methods of fulfilling those motivations. From the role congruity perspective, the motivation to achieve role congruity—to align behavior with the demands of roles—is an important force. Our role congruity account of sex dif...

Which manager should a firm promote to CEO? How do the attributes of a managerial workforce affect firms’ placement decisions and wage offers, and managers’ quit decisions? The existing literature offers trivial answers to this nuanced question. In one class of models, placement decisions are determined on an individual-by-individual basis, so that promotion of one worker does not crowd out ano...

Supply chain managers should redesign their supply chains in response to the introduction of a new product. In particular, to reach performance targets, they should align the supply chain to the new product features. The objective of this paper is to highlight the negative effects of mis-alignment between product features and supply chains and to propose a set of misalignment indicators, along ...

opened the door for new and exciting informationintegration applications. Information sources on the web are controlled by different organizations or people, utilize different text formats, and have varying inconsistencies. Therefore, any system that integrates information from different data sources must identify common entities from these sources. Data from many data sources on the web does n...

This research investigates the usage distribution of instructional resources shared among educators in an online learning community. The usage of a resource is defined by the number of unique educators who use (click on) it. We explored what the usage distribution of these resources looks like and we investigated what underlying mechanisms may have generated the observed distribution. Our resul...

Growth in electronic commerce (EC) continues to exceed growth rates in traditional markets and continues to offer new and different opportunities than traditional businesses. Its failures, however, suggest that many firms are not following successful strategies and have failed to align their EC strategies with business strategies. Observing practices at 12 companies provided insight into the im...