Dermal fibroblast strains from ataxia-telangiectasia (A-T) patients and clinically normal subjects were exposed to 4-nitroquinoline 1-oxide (4NQO) or its 3-methyl derivative (3me4NQO), and their colony-forming abilities and DNA metabolic properties were compared. Three A-T strains, i.e., AT2BE and AT3BI representing genetic complementation group AB and AT4BI belonging to group C, displayed enha...

Two factors are involved in a systematization of the form01 titration. The first of these factors is the titration constant of the amino acid in formaldehyde solution. This aspect has been discussed in a previous paper (4) for certain of the monoamino acids. The basic amino acids will be treated later. The second factor is the behavior of the solvent on the addition of strong alkali, just as th...

UNLABELLED BACKGROUND Previous research on alkaline pretreatment has mainly focused on optimization of the process parameters to improve substrate digestibility. To achieve satisfactory sugar yield, extremely high chemical loading and enzyme dosages were typically used. Relatively little attention has been paid to reduction of chemical consumption and process waste management, which has prov...

Chemical bonding between the Rydberg molecule NH4 and three alkali atoms Li, Na, and K, via their 2s, 3s, or 4s valence orbitals, is examined using flexible atomic orbital basis sets and high level ab initio methods. The results thus obtained suggest that (NH4)Na and (NH4)K should have large enough barriers to fragmentation (to (NH3) plus the alkali hydride) to be detected experimentally if it ...

By the use as tracers of 42K, 86Rb and 32P it has been shown that in the metabolism of Bact. lactis aerogenes (а) the alkali-metal ion enters the cell during oxidation of the carbon substrate (glucose, succinic acid, acetic acid), whether or not a nitrogen source is provided, so that growth occurs; in either event the alkali-metal ion subsequently leaves the cell again; (б) if the pH is lowered...

A beta-(1-5)-galactofuran was isolated and characterized from fraction F1S (alkali- and water-soluble) of the cell wall of most of the species of Eupenicillium. In E. cryptum, E. euglaucum and E. nepalense the galactan contained galactofuranose with different linkages in addition to beta-(1-5). Fraction F1I (alkali-soluble, water-insoluble) was an alpha-glucan in certain species while in others...

The effect of mild alkaline hydrolysis on the immunological reactivity of Salmonella typhimurium lipopolysaccharide (LPS) was studied. Hydrolysis of LPS at 37 C in 0.01 to 0.25 n NaOH caused a decrease in precipitation of LPS by antiserum. Red cells sensitized with alkali-treated LPS were less responsive to hemagglutination by antiserum than were cells sensitized with heated LPS. Hemagglutinati...

hours 30 to 35 per cent of the growth produced in 24 hours by the red blood cell extract and thiamine. This confirms the observation of Berkman and Koser (J. Bact., 41, 38) that slow growth can be obtained in a gelatin hydrolyzate medium with thiamine diphosphate alone and indicates that the alkali-stable portion of the extract is stimulatory, not essential. Attempts to substitute for the alkal...

This is a case of Milk-AlKali syndrome in a patient who presented with the classical triad of hypercalcemia, metabolic alkalosis and renal impairment. The source of calcium was over-the-counter calcium-containing antacid (Tums®). Milk-alkali syndrome was first recognized secondary to treatment of peptic ulcer disease with milk and absorbable alkali. Its incidence fell after the introduction of ...

By J. ARTHUR HARRIS, Head, Department of Botany, University of Minnesota, and Collaborator, Bureau of Plant Industry, United States Department ofAgriculture; W. F. HOFFMAN, Assistant Professor of Agricultural Biochemistry, University of Minnesota, formerly {1920-1924) Field Assistant, Alkali and Drought Resistant Plant Investigations, and Biophysical Investigations, Bureau of Plant Industry, Un...