نتایج جستجو برای: alkaloids

تعداد نتایج: 14570  

Journal: :Anais da Academia Brasileira de Ciencias 2008
Ivo J C Vieira Walter L B Medeiros Cecilia S Monnerat Jucimar J Souza Leda Mathias Raimundo Braz-Filho Angelo C Pinto Priscila M Sousa Claudia M Rezende Rosângela de A Epifanio

The pharmacotherapy for Alzheimer's disease (AD) includes the use of acetylcholinesterase inhibitors (AChEI). Recent investigations for novel AD therapeutic agents from plants suggested that Tabernaemontana genus is a promising source of novel anticholinesterasic indole alkaloids. In this work two fast screening techniques were combined in order to easily identify novel cholinesterase inhibitor...

2014
Elsa Rouah-Martin Walid Maho Jaytry Mehta Sarah De Saeger Adrian Covaci Bieke Van Dorst Ronny Blust Johan Robbens

Ergot alkaloids are mycotoxins which can be found in food based on cereal-crops, due to a contamination of plants by fungi of the genus Claviceps. The ingestion of ergot contaminated cereal crops can lead to a severe poisoning known as ergotism. For food and feed safety purposes, the extraction of ergot alkaloids from ergot contaminated flour was investigated. For the specific recognition of er...

2016
Azeana Zahari Abdulwali Ablat Noridayu Omer Mohd Azlan Nafiah Yasodha Sivasothy Jamaludin Mohamad Mohammad Niyaz Khan Khalijah Awang

The UV-vis spectra of isocorydine 1, norisocorydine 2 and boldine 3 were studied in 2% v/v acetonitrile, at constant ionic strength (0.1 M NaCl, 35 degree Celsius). The pK(a) values of isocorydine 1 and norisocorydine 2 were 11.75 and 12.07, respectively. Boldine 3 gave a pK(a) value of 9.16 and 10.44. All of the alkaloids 1-3 were stable at physiological pH; thereby all of them will not ionize...

Journal: :Molecules 2011
Helene de Wet Fanie R van Heerden Ben-Erik van Wyk

Cissampelos capensis, commonly known by the Afrikaans name "dawidjies" or "dawidjieswortel", is the most important and best known medicinal plant of the family Menispermaceae used by the Khoisan and other rural people in the western region of South Africa. The main alkaloids in the leaves, stems and rhizomes were isolated and identified. Several of the main compounds were previously found in sp...

2018
Fan-Cheng Meng Zheng-Feng Wu Zhi-Qi Yin Li-Gen Lin Ruibing Wang Qing-Wen Zhang

Background Coptidis rhizoma (CR) is the dried rhizome of Coptis chinensis Franch., C. deltoidea C. Y. Cheng et Hsiao or C. teeta Wall. (Ranunculaceae) and is commonly used in Traditional Chinese Medicine for the treatment of various diseases including bacillary dysentery, typhoid, tuberculosis, epidemic cerebrospinal meningitis, empyrosis, pertussis, and other illnesses. Methods A literature ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1995
J W Daly

Poisons are common in nature, where they often serve the organism in chemical defense. Such poisons either are produced de novo or are sequestered from dietary sources or symbiotic organisms. Among vertebrates, amphibians are notable for the wide range of noxious agents that are contained in granular skin glands. These compounds include amines, peptides, proteins, steroids, and both water-solub...

Journal: :Natural product reports 2000
J W Daly H M Garraffo T F Spande M W Decker J P Sullivan M Williams

Research on the nature, structure and biological activity of the toxins present in the skin of poison-dart frogs of South America began in the Laboratory of Chemistry at the National Institutes of Health in the mid-1960s. The presence of toxins in the skin of such frogs had been discovered long ago by Indians of Western Colombia, who to this day use skin secretions from three Colombian species ...

Journal: Journal of Herbal Drugs 2011
Farhad Harriri Hasan Ali Naghdi Badi Rahim Taghizad Farid, Sajjad Sedaghat Shams Ali Rezazadeh Zohreh Kadkhoda,

Background & Aim: Papaver bracteatum Lindl.  (Papaverace) is an important pharmaceutical plant which contains isoqinoline alkaloids. Isoqinoline alkaloids constitute one distinct group of secondary metabolites of the Papaverace family. Codeine and thebaine are important alkaloids of Papaver bracteatum which use widely due to its medicinal properties. Therefore it is...

A. Nofallah M. Gholami M. Piri Sh. Hooshmand*

Background and objectives: More than 40 different alkaloids have been obtained from opium the most important of which are morphine, codeine, papaverine, noscapine and tabaine. Opioid alkaloids produce analgesia by affecting areas of the brain that have peptides with pharmacological pseudo-opioid properties. These alkaloids show important effects on some intracellular peptides l...

Journal: :Journal of natural products 2010
Chew-Yan Gan Tadahiro Etoh Masahiko Hayashi Kanki Komiyama Toh-Seok Kam

Four new bisindole alkaloids of the Strychnos-Strychnos type, leucoridines A-D (1-4), were isolated from the stem-bark extract of Leuconotis griffithii. Alkaloids 1-4 showed moderate cytotoxicity against drug-sensitive and vincristine-resistant human KB cells.

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