The properties of the enzyme alkyl dihydroxyacetone phosphate synthase (1-O-acyl dihydroxyacetone 3-phosphate + ROH 1-0-alkyl dihydroxyacetone 3-phosphate + fatty acid) in Ehrlich ascites tumor cell microsomes were studied utilizing a new assay procedure. The assay is based on the difference of partition coefficient between alkyl dihydroxyacetone-P and hexadecanol in an alkaline two-phase CHC&-...

Abstract: Neurotoxic organotin reagents currently play a key role in radical chemistry. As a result, this is an important area for development of new clean replacement reactions. The pharmaceutical industry in particular has had to avoid use of radical methodology for the formation of carbon–carbon bonds for this reason. With the current dawn in green chemistry, a host of new clean radical meth...

Plasmalogens are a major subclass of ethanolamine and choline glycerophospholipids in which a long chain fatty alcohol is attached at the sn-1 position through a vinyl ether bond. This ether-linked alkyl bond is formed in peroxisomes by replacement of a fatty acyl chain in the intermediate 1-acyl-dihydroxyacetone phosphate with a fatty alcohol in a reaction catalyzed by alkyl dihydroxyacetone p...

Enhancing the selectivity of catalytic processes has potential for substantially increasing the sustainability of chemical production. Herein, we establish relationships between reaction selectivity and molecular structure for a homologous series of key intermediates for oxidative coupling of alcohols on gold using a combination of experiment and theory. We establish a scale of binding for mole...

Euonymus alatus diacylglycerol acetyltransferase ( Ea DAcT) synthesizes the unusually structured 3-acetyl-1,2-diacylgylycerols (acetyl-TAGs) found in the seeds of a few plant species. A member of the membrane-bound O-acyltransferase (MBOAT) family, Ea DAcT transfers the acetyl group from acetyl-CoA to sn -1,2 diacylglycerol (DAG) to produce acetyl-TAGs. In vitro assays demonstrated that the enz...

In this paper we describe the application in QSPR/QSAR studies of a new group of molecular descriptors: atom, atom-type and total linear indices of the molecular pseudograph's atom adjacency matrix. These novel molecular descriptors were used for the prediction of boiling point and partition coefficient (log P), specific rate constant (log k), and antibacterial activity of 28 alkyl-alcohols and...

We report a novel example of electro-mediated photoredox catalysis (e-PRC) in the reductive cleavage C(sp3)?O bonds phosphinated alcohols to alkyl carbanions. As well as deoxygenations, olefinations are reported which E-selective and can be made Z-selective tandem reduction/photosensitization process where both steps photoelectrochemically promoted. Spectroscopy, computation, catalyst structura...

Deracemization of racemic chiral compounds is an attractive approach in asymmetric synthesis, but its development has been hindered by energetic and kinetic challenges. Here we describe a catalytic deracemization method for secondary benzylic alcohols which are important synthetic intermediates end products many industries. Driven visible light only, this based on sequential photochemical dehyd...