Neural blockades are considered an alternative to pharmacotherapy for neuropathic pain although these blockades elicit limited effects. We encountered a patient with postbrachial plexus avulsion injury pain, which was refractory to conventional treatments but disappeared temporarily with the administration of the local anesthetic lidocaine around the left mandibular molar tooth during dental tr...

Patients with advanced gastrointestinal and pelvic malignancies commonly present with pain of varying severity. In a majority of these patients, pain can be effectively managed using an integrated systemic pharmacological approach with oral morphine being the cornerstone of treatment. However, with escalating doses, intolerable side effects of oral morphine may lead to patient dissatisfaction. ...

Nowadays, one cannot but recognize a key role of the peripheral and central glial cells for generation of clinical neuropathic pain. Many cytokines are released from glial cells, immune cells and nociceptive primary afferent central or peripheral terminals by injury, bacterial or viral infection, and envenomation by bee venom or scorpion. Released cytokines mutually affect by paracrine or autoc...

We examined the effect of the opioid receptor agonists and the effect of an antioxidant selol, which is an organoselenium compound on antinociceptive action of opioid agonists in diabetic neuropathic pain model. Streptozotocin (STZ) induced hyperglycemia accompanied by a prolonged decrease in nociceptive threshold is considered a useful model of experimental hyperalgesia. The changes in pain th...

The treatment of osteoarthritis, a disease that eventually affects the majority of the older population, involves the alleviation of symptoms such as pain and stiffness, and the reduction of inflammation. The double-blind, placebocontrolled, crossover study reported here examined the effect of hyben vital, a herbal remedy made from a subtype of rosa canina and recently reported to have anti-inf...

Vertebroplasty and kyphoplasty have become common surgical techniques for the treatment of vertebral compression fractures. Vertebroplasty involves the percutaneous injection of bone cement into the cancellous bone of a vertebral body with the goals of pain alleviation and preventing further loss of vertebral body height. Kyphoplasty utilizes an inflatable balloon to create a cavity for the cem...

Selective blockers of the N-type voltage-sensitive calcium (CaV) channels are useful in the management of severe chronic pain. Here, the structure and function characteristics of a novel N-type CaV channel blocker, SO-3, are reviewed. SO-3 is a 25amino acid conopeptide originally derived from the venom of Conus striatus, and contains the same 4-loop, 6-cysteine framework (C-C-CC-C-C) as O-super...

Flystrike in sheep is a life-threatening condition whereby fly larvae, primarily Lucilia cuprina, infest the flesh, often in the moist, wrinkled, breech area. Mulesing is currently the main method for preventing breech flystrike of sheep in Australia. Although the combination of topical anaesthetic and long-acting non-steroidal anti-inflammatory drugs (NSAIDs) – carprofen was demonstrated to gi...

This study focused on gender discrimination and its impact on development and poverty alleviation. To know the main reasons and areas of gender discrimination and its impact on development and poverty alleviation, the researcher selected 50 (25 male and 25 female) respondents in Hazar Khuani Peshawar on purposive sampling basis from the targeted respondents. Questionnaire was used for educated ...

BACKGROUND Integrative therapies such as massage have gained support as interventions that improve the overall patient experience during hospitalization. Thoracic surgery patients undergo long procedures and commonly have postoperative back, neck, and shoulder pain. PURPOSE Given the promising effects of massage therapy for alleviation of pain, we studied the effectiveness and feasibility of ...