introduction: acute myelogenous leukemia (aml) is a clonal  malignant disease of hematopoietic tissue. the early use of  hematopoietic stem cell transplantation (hsct) for aml was for patients with advanced stages of disease, usually while in relapse, in second or subsequent remission, or with resistant disease. patients and methods: from march 1991 until february 2008, 356(65%) registered allo...

Acute graft-versus-host disease (aGVHD) impairs thymus-dependent T-cell regeneration in recipients of allogeneic bone marrow transplants through yet to be defined mechanisms. Here, we demonstrate in mice that MHC-mismatched donor T cells home into the thymus of unconditioned recipients. There, activated donor T cells secrete IFN-gamma, which in turn stimulates the programmed cell death of thymi...

Posttransplant infection associated with host immune deficiency is the major cause of nonrelapse mortality of human bone marrow transplant recipients. In a new murine model of posttransplant infection, allogeneic bone marrow transplant recipients were infected with herpes simplex virus-1 (HSV-1) via intraperitoneal inoculation 12 weeks after transplantation. Allogeneic transplant recipients wit...

BACKGROUND AND OBJECTIVES Interleukin-7 (IL-7) has been studied for its possible immunorestorative capacities following stem cell transplantation and has been shown to enhance post-transplant immune recovery predominantly by peripheral T-cell expansion. A major concern of IL-7 is its possible aggravating effect on graft-versus-host and host-versus-graft reactivity. DESIGN AND METHODS To study...

Allogeneic bone marrow transplantation (BMT)' has become a major therapeutic modality in the treatment of various malignant and nonmalignant hematologic disorders (1-6) . However, graft-vs.-host disease (GuHD) causes much morbidity and mortality after transplantation (7, 8) . Since GvHD is mediated by immunocompetent T cells in the graft (9, 10), depletion of T cells from the bone marrow graft ...

BACKGROUND The possibility that allogeneic hematopoietic stem cell transplantation performed across the ABO blood group-barrier is associated with an increase of graft-versus-host disease, in particular endothelial damage, has not been elucidated so far. For this reason, we investigated the level of endothelial cell chimerism after allogeneic hematopoietic stem cell transplantation in order to ...

Markedly elevated serum IgE levels have been noted following allogeneic bone marrow transplantation (BMT) and have been correlated with graft-v-host disease (GVHD) in several studies. To investigate this phenomenon. we measured serum IgE levels in 387 allogeneic. 1 43 autologous, and 21 syngeneic BMT recipients before and at intervals after BMT. As a population, allogeneic BMT recipients displa...

Markedly elevated serum IgE levels have been noted following allogeneic bone marrow transplantation (BMT) and have been correlated with graft-v-host disease (GVHD) in several studies. To investigate this phenomenon. we measured serum IgE levels in 387 allogeneic. 1 43 autologous, and 21 syngeneic BMT recipients before and at intervals after BMT. As a population, allogeneic BMT recipients displa...

1. De Renzo A, Pezzullo L, D'Arco A, et al. A five drug regimen (VEBEP) followed by involved field radiotherapy in the treatment of Hodgkin's disease [abstract]. Blood 1998; 92(Suppl. 1):235b (abs. 4009). 2. Flowers MED, Sullivan KM, Martin P, et al. G-CSF stimulated donor peripheral blood infusions as immunotherapy in patients with hematologic malignancies relapsing after allogeneic transplant...

Adoptive T-cell therapy using CD3/CD28 co-stimulation likely requires in vivo generation of antigen specificity. Because CD28 promotes TH1/TC1 (T1) or TH2/TC2 (T2) differentiation, costimulation may generate donor T1 or T2 cells capable of differentially mediating allogeneic graft-versus-tumor (GVT) effects and graft-versus-host disease (GVHD). Costimulation under T1 or T2 conditions indeed gen...