interleukin-10 (il-10) is a potent immunosuppressor which inhibits alloantigenic t cell response. il-10 is also an anti-inflammatory endogenous cytokine. to investigate the predictive significance of endogenous il-10 for acute graft versus host disease (gvhd) following allogeneic bone marrow transplantation (bmt), we performed a prospective study on spontaneous il-10 production in the serum of ...

Objective. To estimate an anti-nociceptive and regenerative potential of adipose-derived mesenchymal stem cells in experimental post-traumatic neuropathy rats. Methods. Neuropathic pain was induced by axotomy technique rat left hind paw (Wistar rats (n=113)). The respective group subjects received ADMSCs dose 1×10<sup>6</sup> cells/kg 2×10<sup>6</sup> into the site sciat...

Background. Despite the modern therapy programs including hematopoietic stem cell transplantation, treatment outcomes for children with acute myeloid leukemia (AML) remain unsatisfactory. The 5‑year overall survival rate is about 70 %. patients relapsed and refractory AML 2 times lower (about 35 %). failure in primary unsatisfactory results make it necessary to optimize protocols. Aim was a lon...

Abstract Graft versus host disease (GVHD) is the major and often lethal complication of allogenic bone marrow transplantation. Prophylactic regimens for GVHD are given as standard pre-transplantation therapy; however, up to 60% these patients develop GVHD, require additional immunosuppressive intervention. We identified a probiotic exopolysaccharide (EPS) that induces inhibitory macrophages tol...

introduction: neuroblastoma is the most common extracranial solid tumor in children, accounting for 8% to 10% of all childhood cancers. significantly, autologous transplantation appeared to have the largest impact on survival for the high risk subset of patients, such as those with n-myc amplified metastatic disease diagnosed after age 2 years. patients and methods: this study includes high ris...

Hepatocyte-like cells (HLCs) differentiated from human induced pluripotent stem (iPS) cells are expected to be applied for regenerative medicine. In this study, we attempted to generate safe and therapeutically effective human iPS-HLCs for hepatocyte transplantation. First, human iPS-HLCs were generated from a human leukocyte antigen-homozygous donor on the assumption that the allogenic transpl...

Background: Antibiotic prophylaxis is usually used in allogenic stem cell transplantation, but its use in Autologous Stem Cell Transplantation (ASCT) is controversial. We evaluated the efficacy of ciprofloxacin prophylaxis in ASCT. Materials and Methods: To identify the efficacy of ciprofloxacin on the incidence of neutropenic fever and its complications, 72 patients had been admitted to Talegh...

Background: Successful pregnancy in allopregnant women depends upon the control of graft rejection mechanisms. It has been suggested that some immunosuppressive cytokines contribute to successful pregnancy and transplantation. Transforming growth factor beta (TGF-   β) exhibits potent immunoregulatory and anti-inflammatory properties which might prolong graft survival. Recent studies suggest a ...