Effective and specific targeting of nanoparticles is of paramount importance in the fields of targeted therapeutics and diagnostics. In the current study, we investigated the targeting efficacy of nanoparticles that were functionalized with two angiogenesis-specific targeting ligands, an alpha(v)beta(3) integrin-specific and a galectin-1-specific peptide. We show in vitro, using optical techniq...

The crystallographic structure of feruloyl esterase from Aspergillus niger has been determined to a resolution of 1.5 A by molecular replacement. The protein has an alpha/beta-hydrolase structure with a Ser-His-Asp catalytic triad; the overall fold of the protein is very similar to that of the fungal lipases. The structure of the enzyme-product complex was determined to a resolution of 1.08 A a...

Methods We included 196 JIA children, 81 boys and 115 girls. Bone mineralization parameters were detected by dual-energy X-ray absorptiometry of lumbar spine L1-L4. Bone biochemical markers were osteocalcine, C-terminal telopeptides (CTT), parathyroid hormone (PTH), Ca, Ca, P, total alkaline phosphatase (TAP) activity. We have detected Sp1 (rs1800012) and -1997G/T (rs1107946) polymorphisms in t...

We present two recursive state space search algorithms that are based on SSS* and Dual*. Both dominate Alpha-Beta on a node count basis and one of them is always faster in searching random trees. These results have been derived on arti cial game trees with negligible leaf node evaluation time. For practical applications with more complex leaf evaluation functions we conjecture that our recursiv...

Myasthenia gravis (MG) and experimental autoimmune MG (EAMG) are T-cell regulated, antibody-mediated diseases. Peptides p195-212 and p259-271 of the human acetylcholine receptor (AChR) alpha-subunit, were previously shown to be immunodominant T cell epitopes in MG patients as well as in SJL and BALB/c mice, respectively. A dual altered peptide ligand (APL) composed of the two single amino acid ...

A Heyting algebra is a distributive lattice with implication and a dual $BCK$-algebra is an algebraic system having as models logical systems equipped with implication. The aim of this paper is to investigate the relation of Heyting algebras between dual $BCK$-algebras. We define notions of $i$-invariant and $m$-invariant on dual $BCK$-semilattices and prove that a Heyting semilattice is equiva...

we study the notion of bounded approximate connes-amenability for‎ ‎dual banach algebras and characterize this type of algebras in terms‎ ‎of approximate diagonals‎. ‎we show that bounded approximate‎ ‎connes-amenability of dual banach algebras forces them to be unital‎. ‎for a separable dual banach algebra‎, ‎we prove that bounded‎ ‎approximate connes-amenability implies sequential approximate...

A dual-band artificial magnetic material and then a dual-band double-negative metamaterial structure based on symmetric spiral resonators are presented. An approximate analytical model is used for the initial design of the proposed structures. The electromagnetic parameters of the proposed metamaterial structure retrieved using an advanced parameter retrieval method based on the causality princ...

objectives: this study aimed to identify elderly fallers and non-fallers by balance test under dual tasks conditions. methods & materials: this study was an analyze-comparative study. subjects were from three park of tehran. subjects were 20 older adults with outhistory of falls (aged 75.95±6.28 years) and 21 older adults with a history of 2 or more falls in the previous one year (aged 72.50±7....