The ultrastructural distribution pattern and site density of alpha-methyldopa immunoglobin G (alpha-MD IgG) on the red cell membrane was observed and compared with that of anti-D IgG, with ferritin-conjugated rabbit anti-human IgG and [125I]anti-D. alpha-MD IgG binds to all common types of human red cells, both Rho (D) positive and negative, to give a random, aperiodic distribution pattern gros...

Several drugs are known to cause a lupus-type syndrome.1 Methyldopa causes positive anti-nuclear antibody reactions, but only two previously reported cases of a methyldopa-induced lupus-type syndrome have been described.23 We report a case of this syndrome which failed to resolve fully on withdrawal of the drug, and which has features of a mixed connective tissue disorder (MCTD). CASE HISTORY A...