BACKGROUND The compound, 1'-S-1'-acetoxychavicol acetate (ACA), isolated from the rhizomes of a Malaysian ethno-medicinal plant, Alpinia conchigera Griff. (Zingiberaceae), was previously shown to have potential in vivo antitumour activities. In the development of a new drug entity, potential interactions of the compound with the cytochrome P450 superfamily metabolizing enzymes need to be ascert...

Since prehistoric era, plant-derived drugs were much preferred due to their less side effects than drugs of synthetic origin. Bioassay-guided selection of active fraction of a plant extract and further isolation and characterization of the pure bioactive compounds are in practice in both academic and industrial research. Zingiberaceae, a medicinally important, ornamental, monocotyledonous famil...

In the present study, the antioxidant potential of the crude methanol and its fractionated extracts (hexane, ethyl acetate and water) of the rhizomes of Alpinia mutica was investigated, employing four different assays. The antioxidant assays used were 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, β-carotene bleaching, superoxide dismutase (SOD) and the reducing power assays while th...

Alpinia intermedia, a perennial plant that belongs to the Zingiberaceae family, has been used in folk medicine for a long time in the southern region of Japan. Because skin care is an effective approach that enables patients to manage their atopic dermatitis (AD), various herbal ingredients with few adverse effects have been evaluated for use in AD patients in recent years. In this study, we ex...

Background: Alpinia galanga belonging to Zingiberaceae family was traditionally used to treat numerous inflammatory disorders. The rationale behind its use since ages has to be scientifically validated for developing newer therapeutic agents. Aims and Objectives: Anti-inflammatory activity of ethanolic extract of A. galanga in carrageenan induced pleurisy rats. Materials and Methods: This study...

Baoquan Kou 1,*, Feng Xing 1, Chaoning Zhang 2, Lu Zhang 1, Yiheng Zhou 1 and Tiecheng Wang 1 1 School of Electrical Engineering and Automation, Harbin Institute of Technology, Harbin 150001, China; [email protected] (F.X.); [email protected] (L.Z.); [email protected] (Y.Z.); [email protected] (T.W.) 2 Faculty of Technology, Policy and Management(TPM), Delft University of Technology, Del...

In our continuing study of biologically active natural products from the fruit of Alpinia galanga (Zingiberaceae), we newly isolated three new labdane-type diterpenes, termed galangalditerpenes A-C (1-3), along with four known sesquiterpenes (4-7) and two diterpenes (8 and 9). The stereostructures of 1-3 were elucidated on the basis of their spectroscopic properties. The melanogenesis inhibitor...