We have generated and characterized a murine monoclonal anti-idiotype (Id) antibody, designated 11D10, which biologically and antigenically mimics a distinct and specific epitope of the high molecular weight human milk fat globule primarily expressed by human breast and some other tumor cells at high density. This epitope is identified by mAb BrE1, which was used as the immunizing antibody or A...

Natural fiber is a renewable resource characterized by its low cost and environmental friendliness. However, flame retardant properties are one of the biggest limitations for the preparation of composite materials that need to be improved. In this work, a novel complex flame retardant consisting of aluminum hydroxide (ALH) and decabromine diphenyl oxide (PBDE) was proposed to inhibit the therma...

The Bayer Process (for alumina) as we know it today involves two steps: • The pressure leaching of bauxite with NaOH solution to obtain sodium aluminate solution. • The precipitation of pure aluminum hydroxide from this solution by seeding with fine crystals of Al(OH)3 . The leaching step was invented five years after the precipitation step (Table 1), and the precipitation step was an improveme...

The immune system represents a promising novel target for prevention of atherosclerosis. Several pilot vaccines that reduce atherosclerosis in experimental animals have been developed. The aluminum hydroxide adjuvant Alum has been shown to have antiatherogenic properties in itself, suggesting that it may be a suitable adjuvant in possible future atherosclerosis vaccines. To characterize the imm...

PURPOSE The aim of this study was to evaluate the effect of provisional cements on the adhesion of resin bonded indirect restorations and determine the best method for avoiding adverse effects. MATERIALS AND METHODS Forty-five bovine incisors were selected, and the enamel removed with a 600-grit SiC abrasive disk to expose superficial dentin. Provisional restorations of acrylic resin were cem...

The description of Th1 and Th2 T cell subsets rationalized the inverse correlation between humoral and cell-mediated immunity. Although Th1 cells were described to support cell-mediated immune responses, their role in supporting certain B cell responses was firmly established. However, there is now a prevailing preconception that provision of B cell help is entirely the domain of Th2 cells and ...

Healthy adult male volunteers were immunized with purified M protein from Group A streptococci. Type 1. The vaccine was administered subcutaneously as an aluminum hydroxide-precipitated antigen in three montly doses. Control subjects received a placebo of the aluminum hydroxide adjuvant. To test the efficacy of the immunization, vaccinees and controls were challenged with a virulent strain of T...

BACKGROUND Patients with aluminum hydroxide adjuvant-induced macrophagic myofasciitis (MMF) complain of arthromyalgias, chronic fatigue and cognitive deficits. This study aimed to characterize brain perfusion in these patients. METHODS Brain perfusion SPECT was performed in 76 consecutive patients (aged 49±10 y) followed in the Garches-Necker-Mondor-Hendaye reference center for rare neuromusc...

Novel honeycomb-like mesoporous aluminum hydroxide (pATH) was synthesized via a facile one-step reaction by employing ZIF-8 as a template. This self-decomposing template was removed automatically under acidic conditions without the need for any tedious or hazardous procedures. Meanwhile, the pore size of pATH was easily modulated by tuning the dimensions of the ZIF-8 polyhedrons. Of paramount i...

BACKGROUND Influenza A H5N1 viruses pose a significant threat to human health. METHODS We conducted a multicenter, randomized, double-blind study in 394 healthy adults. Subjects were randomly assigned to receive 2 intramuscular doses of either saline placebo; influenza A/Vietnam/1203/2004(H5N1) vaccine alone at 45, 30, or 15 microg per dose; vaccine at 15 or 7.5 microg per dose with MF59; or ...