1- and 1,5-Aminoalkylamine substituted anthraquinones (AAQs, 1C3 1,5C3) were peptide coupled to 1-, 2-, 3-pyrrole lexitropsins generate compounds that incorporated both DNA minor groove intercalating moieties. The corresponding platinum(II) amidine complexes synthesized through a synthetically facile amine-to-platinum mediated nitrile ‘Click’ reaction. precursors as well the biologically evalua...

The deposition of chlorhexidine base on thermosensitive N-isopropylacrylamide polymeric microparticles was assessed in this study using energy dispersive X-ray spectrometry (EDXS) in scanning electron microscopy (SEM) setting. Three different types of polymer were synthesized. The PN1 was a polymer with terminal anionic groups resulting from potassium persulphate initiator. The PN2 was synthesi...

The symmetric title mol-ecule, [Hf(C26H40N4Si)Cl4], lies about a twofold rotation axis. The Hf(IV) and Si atoms lie on the rotation axis with all other atoms being in general positions. The Hf(IV) atom is six-coordinated by two N atoms from the N (2),N (2')-(di-methyl-silanedi-yl)bis-(N-tert-butyl-3-methyl-benz-imid-amidate) ligand and four Cl(-) ions in a slightly distorted octa-hedral geometr...

The synthesis and crystal structures of bis(S-methylisothiouronium) (MSTUH)(+), N,N'-bis((3- guanidinopropyl)piperazinium (PipeC3GuaH4)(4+) and hexamidinium (HexaH2)(2+) tetrachloro platinate(ll) salts ( called hereafter PtMSTU, PtPipeC3Gua and PtHexa respectively ) were investigated. These compounds contain the "amidine" function ( - C(=NH)NH(2) ) in which the H atoms supplied by the acid have...

Chiral nonracemic cis-4,5-bis(aryl)imidazolines have emerged as a powerful platform for the development of cancer chemotherapeutics, stimulated by the Hoffmann-La Roche discovery that Nutlin-3 can restore apoptosis in cells with wild-type p53. The lack of efficient methods for the enantioselective synthesis of cis-imidazolines, however, has limited their more general use. Our disclosure of the ...