Solenopsis invicta, the red imported fire ant, represents one of the most devastating invasive species. To understand their sensory physiology, we identified and characterized their Hymenoptera-specific (Hs) TRPA channel, SiHsTRPA. Consistent with the sensory functions of SiHsTRPA, it is activated by heat, an electrophile, and an insect repellent. Nevertheless, SiHsTRPA does not respond to most...

Pedospheric nitrate uptake is closely integrated with the nitrogen (N) status and demand of the whole tree. Signaling substances communicating the N demand of the shoot to the roots are required in an integrated regulatory system. Besides phloem mobility, such signal compounds must have the potential to repress or increase nitrate uptake either at the transcriptional or post-transcriptional lev...

Incubation at approximately physiological conditions of amino acids, peptides, and proteins with 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea or cyclohexyl isocyanate resulted in carbamoylation of the alpha-amino groups of amino acids, the terminal amino groups of peptides and proteins and the epsilon-amino groups of lysine moieties. Carbamoylation of the alpha-amino groups and the terminal ami...

A series of eighteen novel 2-[(4-amino-5pyridin-3-yl-4H-1,2,4-triazol-3-yl)thio]-N-(substituted phenyl) propanamides 3(a-i) and 2-[(4-amino-5-phenyl-4H-1,2,4-triazol-3-yl) thio]-N-(substituted phenyl) propanamides 5(a-i) were synthesized by reacting 4-amino-5-pyridin-3-yl-4H-1,2,4-triazole-3-thiol (2) and 4-amino-5-phenyl-4H1,2,4-triazole-3-thiol (4) with the respective 2-chloro-N-(substituted ...

The antiarrhythmic activity of bis-alkoxyphenyltriazaalkanes 1 and bis-alkoxyphenyldiazaalkanes 2 was analyzed in a model reperfusion arrhythmia rats. It found that the key requirements for compounds this are use 2,3,4 trimethoxyphenyl aromatic pharmacophores presence central nitrogen atom linker. most active were ALM-802 (trihydrochloride N –(2,3,4-trimethoxybenzyl)-N – {2-[(2,3,4-trimethoxybe...

A series of chiral complexes the form Ir(NHC)2(aa)(H)(X) (NHC = N-heterocyclic carbene, aa chelated amino acid, X halide) was synthesized by oxidative addition α-amino acids to iridium(I) bis-NHC compounds and screened for asymmetric transfer hydrogenation ketones. Following optimization reaction conditions, NHC, acid ligands, high enantioselectivity achieved when employing Ir(IMe)2(l-Pro)(H)(I...

  Objective(s): Nowadays, cancer is an important public health problem in all countries. Limitations of current chemotherapy for neoplastic diseases such as severe adverse reactions and tumor resistance to the chemotherapeutic drugs have been led to a temptation for focusing on the discovery and development of new compounds with potential anticancer activity.   Materials and Metho...

GLU(K5) kainate receptor subunits are abundant in pain pathways, including dorsal root ganglia and spinothalamic neurons, as well as in the thalamus and brain stem. A growing body of evidence indicates that the GLU(K5) kainate receptor subtype plays a prominent role in pain transmission, particularly in persistent pain. In the present studies, compounds from a novel series of amino acid GLU(K5)...