Apert’s syndrome is an autosomal dominant inherited disease characterized mainly by achrocephalia due to synostosis of the coronary suture and by usually symmetrical syndactyly involving the four extremities. In most cases the disorder results from a mutation in the father; its prevalence at birth is 1:65,0003 and the incidence in Asians is high.4 Mental retardation is common. The literature sh...

The Conus genus includes around 500 species of marine mollusks with a peculiar 9 production of venomous peptides known as conotoxins (CTX). Each species is able to produce up 10 to 200 different biological active peptides. Common structure of CTX is the low number of 11 aminoacids stabilized by disulfide bridges and post-translational modifications that give rise to 12 different isoforms. μ and...

The growth and performance of cowpea seedlings are negatively impacted by climate change the subsequent occurrence drought stress. Osmotic stress leads to formation reactive oxygen species, causing membrane breakdown, impairs metabolic activities. harmful effects osmotic can be reduced using seed priming techniques. Seeds var. Anaswara were treated with polyethylene glycol (PEG) ?-amino butyric...

the molecular dynamics (md) simulation method is used to assess structural details for humanprion protein (hereafter prpn) and its asp178 asn mutant (hereafter prpm) which causes fatalfamilial insomnia disease. the results reveal that the flexibility and instability increase in prpmcould be related to specific amino acids exposed to the solvent. solvation free energy of prpm is 20kjmot1nni2 mor...

The isoquinoline alkaloids and their biosynthetic relatives include many compounds which show important physiological properties in animals: dopamine, mescaline, morphine, papaverine, and narcotine are pertinent examples. The biosynthetic routes to the members of this family start from the essential aminoacids tyiosine or phenflalanine. Decarboxylation gives a phenethylamine building block (C,-...

Lately, microdeletions of the 22q region, responsible for DiGeorge syndrome or velocardiofacial syndrome, have been increasingly related to neuropsychiatric disorders including schizophrenia and bipolar disorder. These manifestations seem to be related to certain genes located in the hemideleted region such as the proline dehydrogenase (PRODH) and the catechol-o-methyltransferase (COMT) genes. ...

Nonlinear effects in protein dynamics are expected to play role in function, particularly of allosteric nature, by facilitating energy transfer between vibrational modes. A recently proposed method focusing on the non-Gaussian shape of the configurational population near equilibrium projects this information onto real space in order to identify the aminoacids relevant to function. We here apply...