A biological microelectromechanical system (BioMEMS) device was designed to study complementary mitochondrial parameters important in mitochondrial dysfunction studies. Mitochondrial dysfunction has been linked to many diseases, including diabetes, obesity, heart failure and aging, as these organelles play a critical role in energy generation, cell signaling and apoptosis. The synthesis of ATP ...

OPA1 is a dynamin-family GTPase that the central mediator of mitochondrial inner membrane fusion. The Opa1 gene generates both long and short isoforms (l-OPA1 s-OPA1) through proteolytic processing. We identify new s-OPA1 show it functions with l-OPA1 to tune level

In Saccharomyces cerevisiae, mitochondrial fusion requires at least two outer membrane proteins, Fzo1p and Ugo1p. We provide direct evidence that the dynamin-related Mgm1 protein is also required for mitochondrial fusion. Like fzo1 and ugo1 mutants, cells disrupted for the MGM1 gene contain numerous mitochondrial fragments instead of the few long, tubular organelles seen in wild-type cells. Fra...

The composition of the mitochondrial outer membrane is notoriously difficult to deduce by orthology to other organisms, and biochemical enrichments are inevitably contaminated with the closely associated inner mitochondrial membrane and endoplasmic reticulum. In order to identify novel proteins of the outer mitochondrial membrane in Arabidopsis (Arabidopsis thaliana), we integrated a quantitati...

The movement of water accompanying solutes between the cytoplasm and the mitochondrial spaces is central for mitochondrial volume homeostasis, an important function for mitochondrial activities and for preventing the deleterious effects of excess matrix swelling or contraction. While the discovery of aquaporin water channels in the inner mitochondrial membrane provided valuable insights into th...

LIST OF ABBREVIATIONS: AIF, apoptosis inducing factor; CcO, cytochrome c oxidase; • • m, mitochondrial membrane potential; ER, endoplasmic reticulum; EM, electron microscopy; IMM, inner mitochondrial membrane; jp, jimpy mouse; mtCK, mitochondrial creatine kinase; Olg, oligodendrocyte; OMM, outer mitochondrial membrane; PARP, poly (ADP-ribose) polymerase; Plp1, X-linked myelin proteolipid protei...