A novel fluorescent nanosensor has been developed for detecting biothiols including cysteine and glutathione using graphene oxide based hairpin DNA-selective fluorescence quenching and thymine-Hg(II)-thymine coordination-controlled hybridization chain reaction, which provides a simple but the most sensitive platform for biothiol assays.

BACKGROUND Engineering microorganisms in order to improve the metabolite flux needs a detailed knowledge of the concentrations and flux rates of metabolites and metabolic intermediates in vivo. Fluorescence resonance energy transfer (FRET) based genetically encoded nanosensors represent a promising tool for measuring the metabolite levels and corresponding rate changes in live cells. Here, we r...

A new method in differentiation of chiral molecules is reported based on the fluorescence quenching of functionalized CdS quantum dots (CdS-QDs) as nanosensor by differing in the chirality of functionalization species. The chemically functionalized CdS-QDs with strong yellow emission were prepared using chiral L-cysteine (L-Cyst) and D-cysteine (D-Cyst) molecules. Then, the functionalized CdS-Q...

The title compound, [Co(C(30)H(23)O(2)P(2))(C(3)H(9)P)(2)], was synthesized by the addition of a Co(PMe(3))(4) solution to (PPh(2)O)(2)C(6)H(4). The Co(I) atom displays a trigonal-bipyramidal geometry with the two P atoms of the 'PCP' pincer ligand and the P atom of one of the trimethyl phosphine ligands forming the basal plane, whereas the metalated C atom and the P atom of the second phospine...

Cancer proteomics is the manifestation of relevant biological processes in cancer development. Thus, it reflects the activities of tumor cells, host-tumor interactions, and systemic responses to cancer therapy. To understand the causal effects of tumorigenesis or therapeutic intervention, longitudinal studies are greatly needed. However, most of the conventional mouse experiments are unlikely t...

We propose a nanosensor with a biological active part able to identify specific odorants. The biological part should be constituted by olfactory receptors pertaining to the G protein-coupled receptors, the most efficient natural sensors for odorant discrimination. Modeling, design, and experiments performed for proving the concept are reported and discussed.

Coumarin C343 (C(16)H(15)NO(4)), a dye used to enhance the weak chemiluminescence associated with lipid peroxidation, was conjugated to silica nanoparticles and entrapped in a sol-gel matrix to produce a nanosensor capable of enhancing low-level chemiluminescence by approximately 100%.

This study was accomplished to examine the efficiency of natural zeolite in preventing acute toxicity of total ammonia to Huso huso. The study was performed using Water Static Method in 96 hours. Fish averaged 46 ? 5 g in weight and 22 ? 4 cm in total length were exposed to four different concentrations (15, 30, 50, 75 mgL-1) of ammonia and a group was considered as control. Under stable condit...

The resistance to fumigant insecticides in stored-products insects is often recorded. Several factors influence the evolution of insecticide resistance. Among these, the frequency of applications and the migration of resistant populations are of primary importance for the stored-product insects. The aim of this study was to characterize the spectrum and investigate the status of phosphine resis...