Probably the first studies of the pharmacology of quaternary ammonium compounds were made by Crum-Brown and Fraser in 1868. Burn and Dale (1915) found that, unlike nicotine, tetraethyl-ammonium chloride blocked autonomic ganglia without noticeable initial stimulation. Barlow and Ing (1948a and b), Paton and Zaimis (1948a and b), and Balaban et al. (1949) studied the properties of some chemical ...