Fatigue strength of cross-shaped specimens of SPR joints made of SPCC was evaluated at load angles of 0°, 45°, and 90°. For the static strength at load angles of 0°, 45°, and 90°, the maximum loads were determined to be 4890N, 1969N, and 1611N, respectively. Regarding for the relationship between the load amplitude and the number of cycles (Nf), the results were 014 . 0 3 . 2209 − = f amp N P ,...

The positive inotropic effects of catecholamines have been postulated to result from an increase in the intracellular level of cyclic AMP (adenosine 3',5'-monophosphate) produced by activation of adenyl cyclase. Although lack of an inotropic effect by exogenously administered cyclic AMP has cast doubt on this hypothesis, cardiac cells are not readily permeable to cyclic AMP. The N-2'-O-dibutyry...

Machine-learned force fields (MLFFs) are becoming an increasingly important tool in materials science and physics. However, most MLFFs constructed based on density functional theory (DFT) calculations, which come with significant limitations. Here, the authors combine efficient on-the-fly active learning procedure a ∆-machine approach, enabling generation of accuracy that exceeds DFT at modest ...

Stable transformation of Rat-1 fibroblasts by the v-Src oncoprotein results into the constitutive formation of macropinosomes. In the present report, we found that macropinosomes do not fuse with transferrin-containing endosomes and investigated the effects of cyclic AMP as a regulator of macropinocytosis in this cell system. The permeant analogs dibutyryl cyclic AMP and 8-bromo-cyclic AMP, as ...

Natural Language Processing (NLP) is an efficient method for enhancing educational outcomes. In settings, implementing NLP entails starting the learning process through natural acquisition. English teaching and have received increased attention from relevant education departments as integral aspect of new curriculum reform. The environment undergoing extraordinary changes a result constant impr...

In order to address the problem of intra-domain IP traffic engineering efficiently, we have recently proposed Adaptive Multi-Path routing (AMP) as a dynamic algorithmic solution based on a local view of the network. For two real ISP topologies we have demonstrated that our scheme significantly improves network performance while generating only minimal signaling overhead. However, our performanc...

Weld attributes like geometry and cooling rate are strong functions of the welding process parameters such as arc current, voltage and welding peed. A specific weld pool geometry can be produced using multiple sets of these welding variables, i.e., different combinations of arc current, oltage and welding speed. At present, there is no systematic methodology that can determine, in a realistic t...

Initial rate kinetics, product inhibition patterns, and equilibrium kinetics all indicate that cleavage of adenylosuccinate (AMP-S) by yeast adenylosuccinate lyase proceeds primarily by a reaction in which fumarate leaves the enzyme before AMP and cannot bind to free enzyme at kinetically significant concentrations. The alternate path, in which AMP leaves first, could be detected at equilibrium...