BACKGROUND Some Ficus species have been used in traditional African medicine in the treatment of diabetes. The antidiabetic potential of certain species has been confirmed in vivo but the mechanism of activity remains uncertain. The aim of this study was to determine the activity and to investigate the mechanism of antidiabetic activity of ten selected Ficus species through inhibition of α-amyl...

Seed germination plays important roles in the establishment of seedlings and their subsequent growth; however, seed germination is inhibited by salinity, and the inhibitory mechanism remains elusive. Our results indicate that NaCl treatment inhibits rice seed germination by decreasing the contents of bioactive gibberellins (GAs), such as GA1 and GA4, and that this inhibition can be rescued by e...

Exocrine pancreatic secretion stimulated by vasoactive intestinal polypeptide (VIP), which acts through the adenylyl cyclase-cAMP pathway, is potentiated by stimulation with other secretagogues such as CCK and carbachol (CCh). However, the potentiating effect is abolished by the same secretagogues at supramaximal concentrations. In the present study, we examined the mechanisms by which supramax...

Recent studies have shown that vegetables consumption could lower the risk of diabetes mellitus. Therefore, this study sought to investigate the inhibitory effect of Struchium sparganophora (Ewuro Odo) leaf on key enzyme linked to type-2 diabetes (α-amylase and α-glucosidase) as well as assessing the effect of blanching (a commonly practiced food processing technique) of this leafy vegetable on...

The extensive efforts to screen thermophilic fungi and bacteria, isolated from various environmental samples, have resulted in the selection of Thermomucor indicae-seudaticae, Geobacillus thermoleovorans NP33 and G. thermoleovorans NP54 for the production of glucoamylase, amylopullulanase and alpha-amylase, respectively. Submerged and solid-state fermentation processes were optimized for maximi...

Pharmacognosy Research,2022,14,2,195-203.DOI:10.5530/pres.14.2.28Published:April 2022Type:Original ArticleAuthors:Suresh Yarrappagaari, Lavanya Thopireddy, Srinivasulu Cheemanapalli, Venkata Rami Reddy Narala, Kakarla Chandra Mohan, and Rajeswara Saddala Author(s) affiliations:Suresh Yarrappagaari1, Thopireddy2, Cheemanapalli3, Narala4, Mohan2, Saddala1,* 1Division of Ethnopharmacology, Departm...

Cladonia foliacea (CF) is a type of lichen belonging to the Cladoniaceae family, used as traditional medicine for various diseases. It known that CF has strong antioxidant and antidiabetic effects originating from secondary components. However, bioactivity significantly affected by extraction conditions such temperature, liquid/solid ratio, solvent type/concentration. Herein, parameters (temper...