The self-assembly of several classes of amphiphilic peptides is reviewed, and selected applications are discussed. We discuss recent work on the self-assembly of lipopeptides, surfactant-like peptides and amyloid peptides derived from the amyloid-β peptide. The influence of environmental variables such as pH and temperature on aggregate nanostructure is discussed. Enzyme-induced remodelling due...

Protein misfolding causes serious biological malfunction, resulting in diseases including Alzheimer's disease, Parkinson's disease and cataract. Molecules which inhibit protein misfolding are a promising avenue to explore as therapeutics for the treatment of these diseases. In the present study, thioflavin T fluorescence and transmission electron microscopy experiments demonstrated that hemin p...

Depuis la découverte du caractère transmissible des maladies à prions, d’autres neurodégénératives ont été soupçonnées d’être transmissibles. La maladie d’Alzheimer est caractérisée par dépôts cérébraux de peptide β-amyloïde (Aβ, sous forme plaques et angiopathie amyloïdes) protéines Tau hyperphosphorylées (dégénérescences neurofibrillaires, fibres tortueuses, couronnes prolongements cellulaire...