نتایج جستجو برای: amyloid precursor protein processing
تعداد نتایج: 1764108 فیلتر نتایج به سال:
Thioflavin T derivatives are used in positron-emission tomography (PET) studies to detect amyloid protein deposits in patients with Alzheimer disease. These tracers bind extensively to white matter, which suggests that they may be useful in studies of multiple sclerosis (MS), and that proteins resulting from proteolytic processing of the amyloid precursor protein (APP) may contribute to MS. Thi...
Transgenic mice over-expressing mutant human amyloid precursor protein (PDAPP mouse) develop several Alzheimer’s disease (AD)-like lesions including an age-related accumulation of amyloid-?-containing neuritic plaques. Although aged, heterozygous PDAPP mice also exhibit synaptic and glial cell changes, that is characteristic of AD pathology, no evidence of neurodegeneration has been observed. T...
The Arctic mutation interferes with processing of the amyloid precursor protein. The Arctic Alzheimer mutation favors intracellular Aȕ production by making APP less available to Į-secretase. Journal of Neurochemistry, in press.ȕ oligomers are inefficiently measured by enzyme-linked immunosorbent assay. and Johansson AS. Docosahexaenoic acid stimulates non-amyloidogenic APP processing resulting ...
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