We analyse Pollack and Blair’s HC-Gammon backgammon program using a new technique that performs Monte Carlo simulations to derive a Markov Chain model for Imperfect Comparison ALgorithms, called the MICAL method, which models the behavior of the algorithm using a Markov chain, each of whose states represents a class of players of similar strength. The Markov chain transition matrix is populated...

Gene expression experiments are commonly performed using samples that are composed of a variety of cell types, each contributing to the global gene expression measurements in different proportions. The CellMix package defines a general framework for gene expression deconvolution that integrates several of the currently available deconvolution algorithms, and facilitates the estimation of cell t...

How can one possibly analyze computation in general? The task seems daunting if not impossible. There are too many different kinds of computation, and the notion of general computation seems too amorphous. As in quicksand, one needs a rescue point, a fulcrum. In computation analysis, a fulcrum is a particular viewpoint on computation that clarifies and simplifies things to the point that analys...

Identifying the targets and causal mechanisms of phenotypic selection in natural populations remains an important challenge for evolutionary biologists. Path analysis is a statistical modeling approach that may aid in meeting this challenge. We describe several types of path model that are relevant to the analysis of selection, and review some recent empirical studies that apply path models to ...

Immunosuppressant drug toxicity currently competes with acute rejection, as the major cause of efficacy failure of potent new agents in clinical transplantation. The development of mechanistic drug targets as surrogate endpoints for use in the clinic has been facilitated by fluorescent imaging techniques which measure multiple cytokines and cell surface receptors on stimulated (peripheral blood...

In this paper we present a technique for building adaptive wavelets by means of an extension of the lifting scheme and analyze the stability of the resulting decompositions. Our scheme comprises an adaptive update lifting and a fixed prediction lifting step. The adaptivity consists hereof that the system can choose between two different update filters, and that this choice is triggered by the l...

Federal agencies in the United States are required to prepare regulatory impact analyses (RIAs) for every major regulatory action they undertake. Increasingly, other OECD countries are imposing similar requirements. However, there has been little examination of the quality of these documents or of the uses to which they have been put in the regulatory process or elsewhere. In this paper we surv...