Objective: In this paper, we have introduced topoisomerase inhibitors, mechanism of action and types of them. DNA topoisomerases are ubiquitous enzymes that catalyze essential enzymes to solve the topological problems accompanying key nuclear processes such as DNA replication, transcription, repair and chromatin assembly by introducing temporary single or double strand breaks in the DNA. Result...

Objective: In this paper, we have introduced topoisomerase inhibitors, mechanism of action and types of them. DNA topoisomerases are ubiquitous enzymes that catalyze essential enzymes to solve the topological problems accompanying key nuclear processes such as DNA replication, transcription, repair and chromatin assembly by introducing temporary single or double strand breaks in the DNA. Result...

CONTENTS General remarks on information languages Use of the term "Information Language" (IL) Purposes of an information language—requirements for an information language A general model for the structure of the ensemble of subjects Specializations of the general model Indicative and informative descriptions Analytic vs. synthetic relations Paradigmatic vs. syntagmatic relations Synthetic relat...

I J. P. Adoul and M. Barth, “Nearest neighbor algorithm for spherical codes from the Leech lattice,” IEEE Trans. Inform. Theory, vol. 34, pt. 11, pp. 1188-1202, Sept. 1988. Y. Be’ery and B. Shahar, “VLSI Architectures for soft decoding of the Leech lattice and the Golay codes,” Proc. IEEE Int. Workshop on Microekctronics in Commun, Interlaken, Switzerland, Mar. 1991. Y. Be’ery, B. Shahar, and J...

In an era of increasing antimicrobial resistance and few antimicrobials in the developmental pipeline, many institutions have developed antimicrobial stewardship programs (ASPs) to help implement evidence-based (EB) strategies for ensuring appropriate utilization of these agents. EB strategies for accomplishing this include formulary restriction with prior authorization. Potential limitations t...

Let M be a submonoid of the free monoid A∗, and let X ⊆ M be a variable length code (for short a code). X is weakly M-complete if any word in M is a factor of some word in X∗ [J. Néraud, C. Selmi, Free monoid theory: maximality and completeness in arbitrary submonoids, Internat. J. Algorithms Comput. 13(5) (2003) 507–516]. Given a code X ⊆ M , we are interested in the construction of a weakly M...

Adventure game development systems are platforms from the developer’s perspective. This paper investigates several subtle differences between these platforms, focusing on two systems for interactive fiction development. We consider how these platform differences may have influenced authors as they developed systems for simulation and storytelling. Through close readings of Dan Shiovitz’s Bad Ma...