نتایج جستجو برای: and insulin resistance in obese
تعداد نتایج: 21786252 فیلتر نتایج به سال:
it has previously been demonstrated that circulating levels of leptin show ethnic differences when controlled for the confounding influence of adiposity. this study examined leptin levels in non-obese and obese subjects with type 2 diabetes of african versus caucasian origin. materials and methods non-obese and obese subjects with type 2 diabetes of either african origin living in dar es salaam...
In obesity, macrophages and other immune cells accumulate in insulin target tissues, promoting a chronic inflammatory state and insulin resistance. Galectin-3 (Gal3), a lectin mainly secreted by macrophages, is elevated in both obese subjects and mice. Administration of Gal3 to mice causes insulin resistance and glucose intolerance, whereas inhibition of Gal3, through either genetic or pharmaco...
Background: Visfatin is an adipokine secreted from visceral adipose tissue and involved in glucose homeostasis. The aim of the present study was to investigate the effect of eight-week resistance training on plasma visfatin levels and its relation to insulin resistance in insulin-resistant male rats. Methods: In this experimental study twenty-four Wistar male rats (220±20 gr) were acclimati...
Insulin resistance is a pathophysiologic link to development of several metabolic disorders in obese subjects. The aim of this study is to evaluate the association between obesity and insulin resistance using HOMA-IR index in normoglycemic obese subjects and to compare the results with the result of healthy non obese subjects. The importance is to identify the subjects in risk for developing pr...
OBJECTIVE Adipose tIssue regulates insulin sensitivity via the circulating adipocytokines, leptin, resistin and adiponectin. The objective of this study was to compare the levels of resistin, adiponectin and leptin in lean and obese subjects and determine the relationship between circulating adipocytokines and insulin resistance. METHODS We examined plasma levels of resistin, adiponectin and ...
We have developed a method to isolate insulin-responsive human hepatocytes from an intraoperative liver biopsy to study insulin action and resistance in man. Hepatocytes from obese patients with noninsulin-dependent diabetes were resistant to maximal insulin concentration, and those from obese controls to submaximal insulin concentration in comparison to nonobese controls. Insulin binding per c...
There is growing evidence that the postnatal environment can have a major impact on the development of obesity and insulin resistance in offspring. We postulated that cross-fostering obesity-prone offspring to lean, obesity-resistant dams would ameliorate their development of obesity and insulin resistance, while fostering lean offspring to genetically obese dams would lead them to develop obes...
The possible contribution of tumor necrosis factor-α (TNF-α) to the development of obesity-associated insulin resistance in humans is still controversial. Our study investigated the effect of TNF-α neutralization on insulin resistance in healthy, obese and insulin resistant men. We performed a prospective, randomized, double-blind placebo-controlled trial in nine young, healthy obese male subje...
AIM The definition of childhood metabolic syndrome has not been described clearly. Childhood obesity is increasing gradually, and the incidence of childhood metabolic syndrome is also rising. We aimed to show metabolic syndrome components and preventive factors for metabolic syndrome in obese children Methods: In the present study, 187 obese children and adolescents 5-18 years old were investig...
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