Identifying effective therapeutic drug combinations that modulate complex signaling pathways in platelets is central to the advancement of effective anti-thrombotic therapies. However, there is no systems model of the platelet that predicts responses to different inhibitor combinations. We developed an approach which goes beyond current inhibitor-inhibitor combination screening to efficiently c...

Axial SpA (axSpA) is a chronic inflammatory condition predominantly involving the spine and sacroiliac joints (SIJ), with or without extra-spinal manifestations including peripheral arthritis, enthesitis, iritis, psoriasis and IBD. Individuals with axSpA experience significant pain, stiffness and lack of function, which translates into important health care costs and increased mortality. AxSpA ...

INTRODUCTION The sacroiliac joint (SIJ) may be a source of chronic low back pain in 15 -22% of patients. Over the past four years MIS is an emerging standard of care for SI joint fusion. The International Society for the Advancement of Spine Surgery (ISASS) and Society for Minimally Invasive Spine Surgery (SMISS) conducted a survey of their members to examine current preferences in surgeon prac...

Background: Sacroiliac joint (SIJ) movement has been investigated in many studies using a motion analysis system; however, the reliability of this method not well defined yet. Objectives: This study aimed to investigate measuring three-dimensional (3D) SIJ through system. Methods: A total 10 healthy participants performed three forward flexions from standing position twice one session with an i...

Abstract. We introduce a concept of similarity between vertices of directed graphs. Let GA and GB be two directed graphs with respectively nA and nB vertices. We define a nB × nA similarity matrix S whose real entry sij expresses how similar vertex j (in GA) is to vertex i (in GB) : we say that sij is their similarity score. The similarity matrix can be obtained as the limit of the normalized e...

The synergistic effects of daptomycin plus gentamicin or rifampin were tested against 50 Staphylococcus aureus strains, with daptomycin MICs ranging between 0.25 and 8 microg/ml. Daptomycin sub-MICs combined with gentamicin concentrations lower than the MIC yielded synergy in 34 (68%) of the 50 strains. Daptomycin combined with rifampin yielded synergy in one vancomycin-intermediate S. aureus s...

bismuth salts and different antimicrobials including metonidazole & tetracyclines were used in the assessment of inhibition zone of helicobacter pylori cultures on solid media. antibiotics were used or in combined in order to find out their possible synergistic effects. it was showed that: only bismuth substrate and not then salts have antibacterial effects on helicobacter pylori and also on th...

Although the sacroiliac joint (SIJ) is conventionally accepted as a sagittal joint with little mobility in other planes, recent research has shown evidence for reduced hip abduction and axial rotation in patients with sacroiliac pain. A sample of healthy individuals was investigated to determine whether innominate motion about the sacroiliac joint can be predicted from abduction and external ro...

A data set is a matrix D = {f (1), ..., f (m)} (D ∈ Rnx×m), where the rows correspond to objects and the columns are features f (i). A data set is generated by a structure, parameterized by a symmetric matrix S ∈ Rnt×nt . Each row/column in S corresponds to a node in the graph. The set of object nodes is called X and cluster nodes is called Z, where nx and nz are their cardinalities, combining ...