Therapeutic angiogenesis using vascular endothelial growth factor can reduce tissue ischemia by simulating the natural process of angiogenesis. Vascular endothelial growth factor not only stimulates endothelial cells to proliferate and migrate, but also mobilizes endothelial progenitor cells and achieves vascular protection. Besides direct administration of angiogenic proteins, plasmids and vir...

Induction of angiogenesis is a critical and rate-limiting step in the progression of cancer. It is widely acknowledged that this induction requires the concomitant stimulation of pro-angiogenic and repression of anti-angiogenic proteins. It has been demonstrated that in human epithelial cells repression of the angiogenesis inhibitor Thrombospondin-1 (Tsp-1) requires stimulation of Myc in combin...

Angiogenesis has been targeted in retinopathies, psoriasis, and a variety of cancers (colon, breast, lung, and kidney). Among these tumour types, clear cell renal cell carcinomas (RCCs) are the most vascularized tumours due to mutations of the von Hippel Lindau gene resulting in HIF-1 alpha stabilisation and overexpression of Vascular Endothelial Growth Factor (VEGF). Surgical nephrectomy remai...

background: candida albicans is one of the most important opportunistic pathogens that suppress immunologic mechanisms of the host. it is speculated that structural and secretory proteins of c. albicans have immunomodulatory effects in cancer. objective: to evaluate the effects of c. albicans structural and secreted proteins on intratumoral cd4/cd8 ratio as well as the survival rate in balb/c t...

A number of anti-angiogenesis drugs have been FDA-approved and are being used in cancer treatment, and a number of other agents are in different stages of clinical development or in preclinical evaluation. However, pharmacologic anti-angiogenesis strategies that arrest tumor progression might not be enough to eradicate tumors. Decreased anti-angiogenesis activity in single mechanism-based anti-...

Malignant features such as sustained proliferation, refractoriness to growth suppressors, resistance to cell death or aberrant motility and metastasis can be triggered by a variety of mutations and signaling adaptations. Signaling nodes can act as cancer-associated factors by cooperating with oncogene-governed pathways or participating in compensatory transduction networks to strengthen tumor p...

Aging is the strongest risk factor for cardiovascular disease, with progressive decline in function of vascular endothelial cells (ECs) age. Systematic analyses effects aging on different cardiac EC types remain limited. Here, we constructed a scRNA atlas transcriptomes young and old mouse hearts. We identified 10 subclusters. The multidimensionally differential genes (DEGs) analysis across clu...

117: 734-749. Angiogenesis, the formation of new vessels, is regulated by the migration, proliferation and structural re-organisation of the endothelium. It is important in development and tissue homeostasis, while angiogenesis also contributes to the pathogenesis of cancer and ocular disorders (1). Several factors have been implicated in the control of angiogenic signalling. For instance, bone...

Aims: Recombinant proteins rP2 has demonstrated biological activity in inflammation by acting on the recruitment of leukocytes and inducing phagocytosis, also modulating processes angiogenesis fibrogenesis different experimental models. In this study we evaluated effects recombinant protein rP21 from Trypanosama cruzi cutaneous wounds.
 Study Design: The wounds were induced back mice treat...