Vulnerability to emotional disorders including depression derives from interactions between genes and environment, especially during sensitive developmental periods. Across evolution, maternal care is a key source of environmental sensory signals to the developing brain, and a vast body of work has linked quantitative and qualitative aspects of maternal care to emotional outcome in children and...

Anticipatory anhedonia in schizophrenia subjects L'anhédonie anticipatoire dans les schizo-phrénies Dear Editors, The distinction between the experience of pleasure related either to online experience in response to a specific stimulus (consummatory pleasure) or to future pleasurable activities (anticipatory pleasure) has been proposed by Klein [7] in a theoretical paper. Recently, accumulated ...

The temporal location of an event influences the way people mentally represent that event. We suggest (a) that such representational differences can produce an affective forecasting error that we call future anhedonia, which is the belief that hedonic states will be less intense in the future than in the present, and (b) that future anhedonia plays a role in time discounting (i.e., the tendency...

To the Editor: On the basis of the conclusion that more than 50% of US physicians suffer from burnout, Melnick and Powsner and Shanafelt and Noseworthy underlined the importance of taking systemic action to reduce the risk of the syndrome by improving conditions under which physicians work. To effectively deal with the issue of job stress, we think that a critical step is to understand burnout ...

Two human associative-learning experiments investigated the relationship between the negative dimension of schizotypy and selective and nonselective prediction-error learning. Experiment 1 demonstrates that individuals low, but not high, on the introvertive anhedonia dimension of schizotypy demonstrate Kamin blocking, which has been taken to reflect the operation of selective learning (Rescorla...

The extent to which Theory of Mind impairments are a trait associated with schizotypy is unclear. To date, findings have been mixed. We compared two groups of psychometrically identified schizotypes, namely, those characterized by positive schizotypy (perceptual aberrations and magical ideation; n=36) and those characterized by negative schizotypy (social anhedonia; n=30) to a low schizotypy co...

In the research domain framework (RDoC), dysfunctional reward expectation has been proposed to be a cross-diagnostic domain in psychiatry, which may contribute to symptoms common to various neuropsychiatric conditions, such as anhedonia or apathy/avolition. We used a modified version of the Monetary Incentive Delay (MID) paradigm to obtain functional MRI images from 22 patients with schizophren...

Ribot's (1896) long standing definition of anhedonia as "the inability to experience pleasure" has been challenged recently following progress in affective neuroscience. In particular, accumulating evidence suggests that reward consists of multiple subcomponents of wanting, liking and learning, as initially outlined by Berridge and Robinson (2003), and these processes have been proposed to rela...