The effects of acridine derivatives (proflavine and 2,7-dialkyl derivatives, diacridines and triacridines, 9-aminoacridine carboxamides, and 9-anilinoacridine, amsacrine and its congeners) on overall RNA synthesis in vitro, on synthesis of initiating oligonucleotides and the binding of the enzyme to DNA were studied. The primary mechanism of action is related to inhibition of the enzyme binding...

The results of cyclic, differential pulse and square wave voltammetric studies four ferrocene derivatives, i.e., 4-ferrocenyl-3-methyl aniline (FMA), 3-Chloro-4-ferrocenyl (CFA), 4-ferrocenyl (FA) ferrocenyl benzoic acid (FBA) on carbon electrode, revealed that the redox behavior these compounds is sensitive to pH, concentration, scan number rate. One electron, diffusion controlled, with a quas...

Abstract Some N-substituted allylarylamines, for example, N-(1-methyl-2-butenyl) aniline (N-MBA) form, upon isomerization, not only ortho- , but also para- and 2,6-disubstituted derivatives, which does fit into generally accepted theory. The amino-Claisen rearrangement (ACR) of N-MBA is catalyzed by Lewis acids, cationites, arylamine hydrochlorides. This work presents the results studies ACR in...

Quinone methides are fundamental intermediates for a wide range of reactions in which catalyst stereocontrol is often achieved by hydrogen bonding. Herein, we describe the feasibility an intramolecular Friedel–Crafts 6π electrocyclization through ortho-quinone methide iminiums stereocontrolled contact ion pair. A disulfonimide activates racemic trichloroacetimidate substrates and imparts cycliz...

The present paper describes the synthesis of two Azo-Schiff base named (2-(((2-aminophenyl)imino)methyl)-6-ethoxy-4-((Z)-phenyldiazenyl) phenol, 2-((Z)-((4-aminobutyl)imino)methyl)-6-ethoxy-4-((Z)-phenyldiazenyl)phenol) by diazotization reaction synthesized (3-Ethoxy-2-hydroxy benzaldehyde) with aniline compound to gave Al- Azo – aldehyde and reacted (O-phenylenediamine or1,4-butanediamine) bas...

The direct and catalytic incorporation of fluorine containing molecular motifs into organic compounds resulting high-value added chemicals represents a rapidly evolving part synthetic methodologies, thus this area is in the focus pharmaceutical agrochemical research. Herein we report stereoselective procedure for fluorovinylation aromatic heteroaromatic scaffolds. This methodology development h...

With the growing realization that many of the unique properties of macromolecules can be attributed to their specific three-dimensional structure, various chemical and physical techniques have been utilized to study macromolecular conformation. Of these techniques, spectropolarimetry has proved itself to be particularly useful. Studies of the optical rotatory dispersion of macromolecular soluti...

In this study some new compounds have been prepared including thereaction of diazoium salt 1,4-phenylenediamine with 2-mercaptobenzaldehyde at (0-5)0C[F1]. Then Schiff bases [F2-F6] werethen synthesized through the reaction compound [F1] withsubstituteds aniline in absolute ethanol, and were convertedinto 2,3 - dihyroquinazolin 4(1H) one derivatives [F7-F11] by 2-amino benzoic acid ethanol. The...

Comprehensive studies of the molecular and electronic structures, vibrational frequencies, and infrared and Raman intensities of the aniline radical cation, C6H5NH2 1 have been performed by using the unrestricted density functional ~UB3LYP! and second-order Møller–Plesset ~UMP2! methods with the extended 6-31111G~df,pd! basis set. For comparison, analogous calculations were carried out for the ...