OBJECTIVE A thyroid rat model combining functional and anatomical information would be of great benefit for better modeling of thyroid physiology and for absorbed dose calculations. Our aim was to show that (124)I-PET and CT small animal imaging are useful as a combined model for studying thyroid physiology and dose calculation. METHODS Seven rats were subjects for multiple thyroid (124)I-ima...

BACKGROUND Laboratory exercises are intended to illustrate concepts and add an active learning component to courses. Since 1980s, there has been a decline in animal laboratories in medical physiology courses. Other cost-effective non-aninmal alternatives are being sought. The present study was designed to find out the students' opinion regarding the animal versus computer lab and whether innova...

There are many limitations for conducting liver disease research in human beings due to the high cost and potential ethical issues. For this reason, conducting a study that is difficult to perform in humans using appropriate animal models, can be beneficial in ascertaining the pathological physiology, and in developing new treatment modalities. However, it is difficult to determine the appropri...

ALTEX 22, Special Issue 2, 2005 46 Alternatives to Animal Experimentation in Undergraduate Curricula at Medical Schools – Analysis of Current Trends in the Czech Republic Miroslav Cervinka, Emil Rudolf 1 and Zuzana Cervinkova Charles University Faculty of Medicine, Department of Medical Biology and Genetics, Hradec Kralove, Czech Republic; Charles University Faculty of Medicine, Department of P...

Preface Mammalian temperature regulation has been the subject of scientific investigation since the advent of thermometers that could be inserted into an orifice of the body. Thousands of research articles, review articles, and book chapters have been written on the subject. A substantial portion of the Handbooks of Physiology Section 4: Environmental Physiology (American Physiological Society,...

Some eight years ago Martin Wikelski and I started musing about how physiological knowledge and tools could be used to understand conservation problems. We were certainly not the first to do so, but we were able to codify the idea by coining the term ‘conservation physiology’ (Wikelski and Cooke, 2006), which has been embraced by many. When the leadership at the Society of Experimental Biology ...

Altex 31, 2/14 224 Alternatives Initiative in Sri Lanka: Preand Post-Conference Workshops at the Inaugural Scientific Conference of the Sri Lanka Association for Laboratory Animal Science Mangala Gunatilake 1, Francois Busquet 2, and Mohammad A. Akbarsha 3 Department of Physiology, Faculty of Medicine, University of Colombo, Sri Lanka; Center for Alternatives to Animal Testing (CAAT)-Europe, Ko...

Labor is a physiological event involving a sequential, integrated set of changes within the myometrium, deciduas, and uterine cervix that occur gradually over a period of days to weeks. Biochemical connective tissue changes in the uterine cervix appear to precede uterine contractions and cervical dilation, and all of these events usually occur before rupture of the fetal membranes. In other wor...

TJF: SF Services, PO Box 5489, Little Rock, Arkansas, 72119; RCT: University of Missouri-Columbia, Commercial Agriculture Program, W234 College of Veterinary Medicine, Columbia, Missouri 65211; BAB: USDA-ARS, Animal Physiology Unit, Columbia, Missouri; MLM, Dept. Molecular Microbiology and Immunology, School of Medicine, University of Missouri-Columbia; GLA: 5-133D Animal Science Center, Univer...

HISASHI KISHI,1 MARIKO ITOH,2 KEN-ICHI OHSHIMA,3 MING-WEI WANG,2 GEN WATANABE,3 AND KAZUYOSHI TAYA3 1Department of Animal Reproduction, National Institute of Animal Industry Ministry of Agriculture, Forestry and Fisheries, Tsukuba, Ibaraki 305-0991; 2Primate Research Institute, Kyoto University, Inuyama, Aichi 484-8506; 3Laboratory of Veterinary Physiology, Tokyo University of Agriculture and T...