Ulcerative colitis and Crohn’s disease are defined by a common term of inflammatory bowel disease. These chronic diseases result in significant morbidity and mortality. While there are no cures for these diseases, the last two decades have been a period of major advancement in our understanding of the biology of intestinal inflammation. This can be attributed to a steadily increasing number of ...

Ten crossbred sows were used per treatment to determine production and composition of milk and litter growth. Treatment 1 consisted of a basal diet plus animal fat from d 109 of gestation until farrowing, then only the basal diet through lactation. Treatment 2 was the same level of basal diet plus animal fat from d 109 of gestation to d 21 of lactation. Treatment 3 was the basal diet plus corns...

Zinc (Zn) is an essential, common metal in animal tissues. Zn levels were elevated in only four tissues after Zn administration, the highest increase being in the pancreas. Zn concentration was increased by metallothionein induction. Metallothionein-bound Zn significantly reduced the toxicity of the metals Cd, Cu and Hg. It should be noted that tissue Zn levels are different in experimental ani...

The interaction of activated leukocytes with the rheumatoid synovial environment is a key process in arthritis. Understanding this process will play an important role in designing effective treatments. In vivo imaging approaches combined with molecular genetics in animal models provide important tools to address these issues. The present review will focus on approaches to in vivo imaging, with ...

Age-related hearing loss (ARHL) affects one in three people older than 65 years and is the most prevalent sensorineural deficit. This type of precedes accelerates onset cognitive impairment associated with an increased risk for neurodegenerative diseases such as dementia Alzheimer disease. The progression ARHL influenced by genetic factors, which are still poorly understood, environmental parti...

Intravital imaging, the microscopic visualization of cellular events in living animals, is becoming a powerful tool for the study of many disease processes. The development of the mammary imaging window has been shown to be advantageous for high resolution imaging for the study of cell movements within an organism and can be used to allow the precise observation of cells and tumor angiogenesis ...

Over the past several years, research has indicated that an individual's genetic makeup strongly influences not only their likelihood of developing depression, but also whether or not they will respond well to a particular antidepressant treatment. Identifying those genes regulating susceptibility to depression will increase our understanding of disease pathophysiology and direct the developmen...

Aortic aneurysm is a common and life-threatening disease that can cause death from rupture. Current therapeutic options are limited to surgical or endovascular procedures because no pharmacological approaches have been proven to decrease the chance of expansion or rupture. The best approach to the management of aortic aneurysm would be the understanding and prevention of the processes involved ...