Leukaemia is a heterogeneous hematologic malignancy characterized by unregulated proliferation of the early blood-forming cells which starts in bone marrow. The basic strategy leukaemia therapy involves induction leukemic apoptosis. Research on natural products have shown that some plant derivatives anticancer properties inducing apoptosis cells. Plants such as Camellia sinensis and Phyllanthus...

Abstract Asthma is a respiratory disease with dramatically increasing incidence globally. The present study explored the roles of S-phase kinase-associated protein 2 (SKP2) and forkhead box O3 (FOXO3) in asthma their involvement Krüppel-like factor 15–lipoprotein receptor-related 5 (KLF15–LRP5) axis. SKP2 expression patients OVA-induced asthmatic Sprague Dawley rats was detected by reverse tran...

Abstract The ovary contains numerous macrophages, and macrophage depletion in mice leads to dysfunctional ovulation. Macrophage function the is presumed be related efferocytosis, however, absence of macrophages also disrupts follicular development corpus luteum development. Granulosa cells (GC) are critical ovarian follicle survival, we hypothesized that macrophage-GC crosstalk promoted GC func...

Primula auriculata (Tootia) is one of the most important local medicinal plants in Hamedan district, Iran. To investigate cytotoxicity and apoptosis induction of crude methanolic extract and different fraction of it we compared several methods on HT-29 human colon Adenocarcinoma cells. Cancer cell proliferation was measured by 3-(4, 5‑dimethylthiazolyl)-2, 5‑diphenyl‑tetrazolium bromide (MTT) a...

Recent advances in molecular medicine have proposed new therapeutic strategies for cancer. One of the molecular research lines for the diagnosis and treatment of cancer is the use of long non-coding RNAs (LncRNAs) which are a class of non-coding RNA molecules longer than 200 base pairs in length that act as the key regulator of gene expression. Different aspects of cellular activities like cell...

Osteoporosis is one of the common degenerative skeletal diseases whose essential mechanism imbalance between bone resorption and formation. Currently, close coordination signaling pathways at genetic level during development a hot topic osteoporosis research. The present study focused on whether pterostilbene protects against hydrogen peroxide (H2O2)-induced osteoblastic cell apoptosis, oxidati...

umbilical cord blood (ucb) has been used for transplantation in the treatment of hematologic disorders as a source of hematopoietic stem cells (hscs). because of insufficient number of cord blood cd34+ cells, the expansion of these cells seems to be important for clinical application. mesenchymal stromal cells (mscs), playing an important role in hscs maintenance, were used as feeder layer. apo...

background: alzheimer’s disease (ad) is a progressive neurodegenerative disease and nowadays the role of endothelial cell (ec) injury has been proposed in pathological process in ad. peroxisome proliferator‑activated receptor‑γ (ppar‑γ) agonist has anti‑inflammatory properties through activation in glial cells and improves vascular function and prevent atherosclerotic disease progression. the a...