BACKGROUND In vitro and animal studies have shown that moxifloxacin-containing combinations may improve the bactericidal efficacy of antituberculosis regimens. PATIENTS AND METHODS We measured the decline in the sputum viable count of 13 patients who were given a combination of moxifloxacin 400 mg daily and isoniazid 300 mg daily. RESULTS The time required to reduce the viable count by 50% ...

Previous studies have shown that the proton pump inhibitor omeprazole has antimalarial activity in vitro. The interactions of omeprazole with commonly used antimalarial drugs were assessed in vitro. Omeprazole and quinine combinations were synergistic; however, chloroquine and omeprazole combinations were antagonistic. Artemisinin drugs had additive antimalarial activities with omeprazole.

Fusarium oxysporum, a common fungal pathogen that infects economic crops, causes wilt disease to Saposhnikovia divaricata at an annual incidence rate of more than 15%. This study aimed assess the potential rhizospheric fungi as antifungal agents against divaricata. In this study, 104 were isolated from S. soil. Twelve strains showed antagonistic activity F. MR-16, MR-32, MR-38, etc., screened o...

Pemetrexed (MTA) is a multitargeted antifolate drug approved for lung cancer therapy. Clinically, supplementation with high doses of folic acid (FA) and vitamin B12 (VB12) lowers MTA cytotoxicities. An antagonistic effect of FA/VB12 on MTA efficacy has been proposed. However, patients who receive FA/VB12 show better tolerance to MTA with improved survival. The aims of this study are to investig...

The present investigation was carried out to isolate and characterize antagonistic bacteria against wilt causing fungal pathogen i.e. Fusarium oxysporum, from the rhizosphere of tomato. Fifty-six bacterial strains were isolated from the rhizosphere soil samples of healthy tomato fields, collected from different locations of Faridabad district, Haryana, India. Out of these, ten isolates were fou...

Introduction: Cutaneous Leishmaniasis (CL) is a parasitic disease caused by Leishmania species. Currently accessible treatments remain insufficient, and there is pressure to develop suitable and effectual options. In this study, we used different concentrations of podophyllin in vitro on leishmania parasites and then on leishmaniasis lesions in mice and compared their efficacy. Method: We used ...

FR160, a catechol iron chelator, and tetracyclines or norfloxacin exert in vitro additive or synergistic activity against a chloroquine-resistant Plasmodium falciparum clone. FR160 shows antagonistic effects in association with macrolides, ofloxacin, and rifampin.